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Pramipexole

Name: Pramipexole
Brand: TargetMol
SKU: T1476
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1476Cas No. 104632-26-0

Alias SND 919

Pramipexole (SND 919) is a selective dopamine receptor agonist used in the therapy of Parkinson disease. Pramipexole therapy is associated with a low rate of transient serum enzyme elevations during treatment but has not been implicated in cases of clinically apparent acute liver injury.

Pramipexole

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Purity: 99.96%

Catalog No. T1476Alias SND 919Cas No. 104632-26-0

Pack Size	Price	USA Warehouse	Global Warehouse
500 mg	$30	In Stock	In Stock
1 g	$47	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$32	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.96%

Color:White

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COA HNMR HPLC

Product Introduction

Pramipexole AI Summary

Pramipexole exhibits high binding affinity for human dopamine receptor subtypes D3 (Ki = 0.45 nM) and D2 long (Ki = 27.0 nM), with moderate affinity for D2 short (Ki = 60.0 nM) and D4.4 (Ki = 8.5 nM). It shows agonist activity at these subtypes, with respective EC50 values of 1.0 nM for D3, 9.2 nM for rat D2 long, and 15.0 nM for human D4.2 receptors. Pramipexole also demonstrates high intrinsic activity (up to 100.0%) across these receptors, indicating its strong potential to modulate dopaminergic activity. Additionally, Pramipexole exhibits antiviral activities, notably inhibiting SARS-CoV-2 in VERO-6 cells, and interacts broadly with other receptor types including serotonin and histamine receptors, as well as demonstrating moderate liver toxicity and significant affinity for tyrosyl-DNA phosphodiesterase 1. It has high solubility and oral bioavailability (90.0%), making it a promising candidate for further pharmacological investigations..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Pramipexole (SND 919) is a selective dopamine receptor agonist used in the therapy of Parkinson disease. Pramipexole therapy is associated with a low rate of transient serum enzyme elevations during treatment but has not been implicated in cases of clinically apparent acute liver injury.
Targets&IC50	D2S receptor:3.9 nM(Ki), D4 receptor:5.1 nM(Ki), D2L receptor:2.2 nM(Ki), D3 receptor:0.5 nM(Ki)
Synonyms	SND 919

Chemical Properties

Molecular Weight	211.33
Formula	C₁₀H₁₇N₃S
Cas No.	104632-26-0
Smiles	CCCN[C@H]1CCc2c(C1)sc(N)n2
Relative Density.	1.17 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 75 mg/mL (354.9 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 39 mg/mL (184.55 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.46 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.7319 mL	23.6597 mL	47.3194 mL	236.5968 mL
5 mM	0.9464 mL	4.7319 mL	9.4639 mL	47.3194 mL
10 mM	0.4732 mL	2.3660 mL	4.7319 mL	23.6597 mL
20 mM	0.2366 mL	1.1830 mL	2.3660 mL	11.8298 mL
50 mM	0.0946 mL	0.4732 mL	0.9464 mL	4.7319 mL
100 mM	0.0473 mL	0.2366 mL	0.4732 mL	2.3660 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Pramipexole

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