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GDC-0834

Name: GDC-0834
Brand: TargetMol
SKU: T11379
Rating: 4.5 (1 reviews)

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Catalog No. T11379Cas No. 1133432-49-1

GDC-0834 is a potent and selective BTK inhibit that inhibits BTK with an in vitro IC50 of 5.9 nM (biochemical assays) and 6.4 nM (cellular assays), and with an in vivo IC50 of 1.1 μM (mouse) and 5.6 μM (rat).

GDC-0834

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Catalog No. T11379Cas No. 1133432-49-1

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$198	7-10 days	7-10 days
5 mg	$399	7-10 days	7-10 days
1 mL x 10 mM (in DMSO)	$546	7-10 days	7-10 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	GDC-0834 is a potent and selective BTK inhibit that inhibits BTK with an in vitro IC50 of 5.9 nM (biochemical assays) and 6.4 nM (cellular assays), and with an in vivo IC50 of 1.1 μM (mouse) and 5.6 μM (rat).
Targets&IC50	BTK:5.9 nM
In vitro	GDC-0834 is shown to be a potent reversible inhibitor of six known aldehyde oxidase (AO) substrates with IC50 values ranging from 0.86 to 1.87 μM.?GDC-0834 suppresses BTK kinase activity with an IC50 value of 5.9±1.1 nM with Hill slope value of ?0.84±0.07 (mean±S.E.).
In vivo	In a rat collagen-induced arthritis (CIA) study, GDC-0834 exhibits a dose-dependent inhibition of phosphorylated Bruton's tyrosine kinase (pBTK-Tyr223) in rat blood. The estimated half-maximal inhibitory concentration (IC50) for pBTK-Tyr223 inhibition in rats is 5.6±1.6 μM, demonstrating a moderate potency with a mean (m) value of 0.51±0.087. Furthermore, treatment with GDC-0834 in BALB/c mice demonstrates dose-dependent suppression of pBTK-Tyr223, with dosages of 150 or 100 mg/kg achieving nearly complete inhibition (97% and 96%, respectively) of pBTK-Tyr223 levels in the blood after 2 hours.

Chemical Properties

Molecular Weight	596.74
Formula	C₃₃H₃₆N₆O₃S
Cas No.	1133432-49-1
Smiles	CN1CCN(C)C(=O)[C@H]1c1ccc(Nc2nc(cn(C)c2=O)-c2cccc(NC(=O)c3cc4CCCCc4s3)c2C)cc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 32 mg/mL (53.62 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6758 mL	8.3789 mL	16.7577 mL	83.7886 mL
5 mM	0.3352 mL	1.6758 mL	3.3515 mL	16.7577 mL
10 mM	0.1676 mL	0.8379 mL	1.6758 mL	8.3789 mL
20 mM	0.0838 mL	0.4189 mL	0.8379 mL	4.1894 mL
50 mM	0.0335 mL	0.1676 mL	0.3352 mL	1.6758 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc