PD-L1 Protein, Cynomolgus, Recombinant (His)

Catalog No. TMPJ-00638 Copy Product Info

PD-L1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 32-40 KDa and the accession number is G7PSE7.

PD-L1 Protein, Cynomolgus, Recombinant (His)

Catalog No. TMPJ-00638

Copy Product Info

PD-L1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 32-40 KDa and the accession number is G7PSE7.

Pack Size	Price	USA Stock	Global Stock
5 μg	$68	7-10 days	7-10 days
10 μg	$110	7-10 days	7-10 days
20 μg	$169	7-10 days	7-10 days
50 μg	$310	7-10 days	7-10 days
100 μg	$492	7-10 days	7-10 days
200 μg	$819	7-10 days	7-10 days
500 μg	$1,570	7-10 days	7-10 days
1 mg	$2,230	7-10 days	7-10 days

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For In stock only · Estimated delivery:USA Stock (1-2 days) Global Stock (5-7 days)

For research use only—not for human use. No sales to individuals. Use as intended only.

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Biological Activity	1. Loaded Cynomolgus PD-L1-His on HIS1K Biosensor, can bind Anti-Human PDL1 mAb-Fc with an affinity constant of <10^-3 nM as determined in BLI assay. (Regularly tested) 2. Immobilized Anti-Human PDL1 mAb-Fc at 2μg/ml (100 μl/well)can bind Cynomolgus PD-L1-His. The ED50 of Cynomolgus PD-L1-His is 67.12 ng/ml. (Regularly tested)
Description	PD-L1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 32-40 KDa and the accession number is G7PSE7.
Species	Cynomolgus
Expression System	HEK293 Cells
Tag	C-6xHis
Accession Number	G7PSE7
Synonyms	Programmed death ligand 1,programmed cell death 1 ligand 1,PDL1PDCD1 ligand 1,PD-L1B7 homolog 1,PD-L1,PDL1,PDCD1LG1,PDCD1L1,CD274 molecule,CD274 antigenMGC142294,CD274,B7H1PDCD1L1,B7-H1,B7H1,B7-H
Amino Acid	Phe19-Thr239
Construction	Phe19-Thr239
Protein Purity	Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Molecular Weight	32-40 KDa (reducing condition)
Endotoxin	< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
Reconstitution	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Stability & Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Research Background	CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.