Shopping Cart

Your shopping cart is currently empty

ICILIN

Name: ICILIN
Brand: TargetMol
SKU: T1814
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

🥰Excellent

Catalog No. T1814Cas No. 36945-98-9

Alias AG-3-5

ICILIN (AG-3-5) is a synthetic TRPM8 ion channel super-agonist.

ICILIN

Copy Product Info

🥰Excellent

Purity: 98.64%

Catalog No. T1814Alias AG-3-5Cas No. 36945-98-9

ICILIN (AG-3-5) is a synthetic TRPM8 ion channel super-agonist.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$31	In Stock	In Stock
10 mg	$52	In Stock	In Stock
25 mg	$98	In Stock	In Stock
50 mg	$182	In Stock	In Stock
100 mg	$312	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$34	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:98.64%

Appearance:Solid

Color:White to Yellow

Resource Download

COA HPLC HNMR

Product Introduction

ICILIN AI Summary

ICILIN exhibits a diverse range of biological activities. It acts as an agonist at the TRPM8 and TRPA1 receptors, with EC50 values of 60.0 nM and 100,000.0 nM, respectively, in HEK293 cells. For rat recombinant TRPM8, it shows an EC50 of 190.0 nM for agonist activity and an IC50 of 58.0 nM for antagonist activity against icilin-induced responses. It also presents moderate potency as an inhibitor of Tyrosyl-DNA Phosphodiesterase (TDP1) with a potency of 50.1 nM and inhibits the NFkB signaling pathway with a potency of 28183.8 nM. Additionally, ICILIN has shown antiviral activity against SARS-CoV-2, inhibiting cytotoxicity in various cell types, including Caco-2 and VERO-6 cells. Lastly, it exhibits TRPM8 receptor inhibition with an EC50 of 300.0 nM and shows variable effects on cell viability and growth rates across different cell lines, indicating its complex bioactivity profile..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	ICILIN (AG-3-5) is a synthetic TRPM8 ion channel super-agonist.
Synonyms	AG-3-5

Chemical Properties

Molecular Weight	311.29
Formula	C₁₆H₁₃N₃O₄
Cas No.	36945-98-9
Smiles	Oc1ccccc1N1CC=C(NC1=O)c1cccc(c1)[N+]([O-])=O
Relative Density.	1.415 g/cm3

Storage & Solubility Information

Storage

store under nitrogen | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (192.75 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.42 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2124 mL	16.0622 mL	32.1244 mL	160.6219 mL
5 mM	0.6425 mL	3.2124 mL	6.4249 mL	32.1244 mL
10 mM	0.3212 mL	1.6062 mL	3.2124 mL	16.0622 mL
20 mM	0.1606 mL	0.8031 mL	1.6062 mL	8.0311 mL
50 mM	0.0642 mL	0.3212 mL	0.6425 mL	3.2124 mL
100 mM	0.0321 mL	0.1606 mL	0.3212 mL	1.6062 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc