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ICILIN

Name: ICILIN
Brand: TargetMol
SKU: T1814
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T1814Cas No. 36945-98-9

Alias AG-3-5

ICILIN (AG-3-5) is a synthetic TRPM8 ion channel super-agonist.

ICILIN

🥰Excellent

Purity: 98.64%

Catalog No. T1814Alias AG-3-5Cas No. 36945-98-9

ICILIN (AG-3-5) is a synthetic TRPM8 ion channel super-agonist.

Pack Size	Price	Availability
5 mg	$31	In Stock
10 mg	$52	In Stock
25 mg	$98	In Stock
50 mg	$182	In Stock
100 mg	$312	In Stock
1 mL x 10 mM (in DMSO)	$34	In Stock

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:98.64%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	ICILIN (AG-3-5) is a synthetic TRPM8 ion channel super-agonist.
Synonyms	AG-3-5

Chemical Properties

Molecular Weight	311.29
Formula	C₁₆H₁₃N₃O₄
Cas No.	36945-98-9
Smiles	Oc1ccccc1N1CC=C(NC1=O)c1cccc(c1)[N+]([O-])=O
Relative Density.	1.415 g/cm3
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (192.75 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.42 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2124 mL	16.0622 mL	32.1244 mL	160.6219 mL
5 mM	0.6425 mL	3.2124 mL	6.4249 mL	32.1244 mL
10 mM	0.3212 mL	1.6062 mL	3.2124 mL	16.0622 mL
20 mM	0.1606 mL	0.8031 mL	1.6062 mL	8.0311 mL
50 mM	0.0642 mL	0.3212 mL	0.6425 mL	3.2124 mL
100 mM	0.0321 mL	0.1606 mL	0.3212 mL	1.6062 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc