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PBRM1-BD2-IN-7

🥰Excellent
Catalog No. T60155Cas No. 2819989-68-7

PBRM1-BD2-IN-7, a selective and cell-active inhibitor targeting the polybromo-1 (PBRM1) bromodomain, demonstrates inhibitory efficacy against PBRM1-BD2 with an IC50 value of 0.29 μM. This compound is utilized in cancer research.

PBRM1-BD2-IN-7

PBRM1-BD2-IN-7

🥰Excellent
Purity: 99.41%
Catalog No. T60155Cas No. 2819989-68-7
PBRM1-BD2-IN-7, a selective and cell-active inhibitor targeting the polybromo-1 (PBRM1) bromodomain, demonstrates inhibitory efficacy against PBRM1-BD2 with an IC50 value of 0.29 μM. This compound is utilized in cancer research.
Pack SizePriceAvailabilityQuantity
1 mg$117In Stock
5 mg$269In Stock
10 mg$395In Stock
25 mg$592In Stock
50 mg$834In Stock
100 mg$1,120In Stock
500 mg$2,260In Stock
1 mL x 10 mM (in DMSO)$252In Stock
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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Batch Information

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Purity:99.41%
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COA LCMS

Product Introduction

Bioactivity
Description
PBRM1-BD2-IN-7, a selective and cell-active inhibitor targeting the polybromo-1 (PBRM1) bromodomain, demonstrates inhibitory efficacy against PBRM1-BD2 with an IC50 value of 0.29 μM. This compound is utilized in cancer research.
In vitro
PBRM1-BD2-IN-7 (0, 0.1, 1, and 10 μM; 5 days) selectively inhibits the growth of a PBRM1-dependent prostate cancer cell line, with an IC50 value of 0.29 μM for PBRM1-BD2 inhibitory activity[1].
Chemical Properties
Molecular Weight286.76
FormulaC16H15ClN2O
Cas No.2819989-68-7
SmilesO=C1C=2C(NC(N1)C3=C(C)C=CC=C3C)=CC=CC2Cl
Relative Density.1.228 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 55 mg/mL (191.8 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.4872 mL17.4362 mL34.8724 mL174.3618 mL
5 mM0.6974 mL3.4872 mL6.9745 mL34.8724 mL
10 mM0.3487 mL1.7436 mL3.4872 mL17.4362 mL
20 mM0.1744 mL0.8718 mL1.7436 mL8.7181 mL
50 mM0.0697 mL0.3487 mL0.6974 mL3.4872 mL
100 mM0.0349 mL0.1744 mL0.3487 mL1.7436 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

PBRM1-BD2-IN-7PBRM1BD2IN7EpigeneticReaderDomainEpigenetic Reader Domain
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