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MRP

Multidrug resistance proteins (MRPs) are members of the C family of a group of proteins named ATP-binding cassette (ABC) transporters. These ABC transporters together form the largest branch of proteins within the human body. The MRP family comprises of 13 members, of which MRP1 to MRP9 are the major transporters indicated to cause multidrug resistance in tumor cells by extruding anticancer drugs out of the cell.

Cyclophosphamide
T0707L50-18-0
Cyclophosphamide is a synthetic alkylating agent chemically related to nitrogen mustards. It possesses antitumor and immunosuppressive activities and is widely used in the treatment of various cancers. Additionally, cyclophosphamide is commonly used to induce animal models of premature ovarian failure, bone marrow suppression, cystitis, overactive bladder, and myocarditis.
  • $35
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TargetMol | Inhibitor Hot
Cholesterol
T076057-88-5
Cholesterol is the primary sterol in mammals, accounting for approximately 20–25% of the plasma membrane structure. It plays a key role in regulating membrane fluidity, permeability, and protein function. As an endogenous agonist of estrogen-related receptor α (ERRα), cholesterol is widely involved in metabolic regulation and serves as a precursor for the synthesis of hormones and bile acids. It is commonly used in experimental models of hyperlipidemia.
  • $45
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Fluoxetine
T045054910-89-3
Fluoxetine (LY-110140) is a highly specific serotonin uptake inhibitor and selective 5-hydroxytryptamine (5-HT) reuptake inhibitor. Fluoxetine has antidepressant activity.
  • $30
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Cyclophosphamide hydrate
T07076055-19-2
Cyclophosphamide hydrate is a synthetic alkylating agent structurally related to nitrogen mustards, with antitumor and immunosuppressive activities. It is widely used in the treatment of various cancers and is also commonly employed to induce animal models of premature ovarian failure, myelosuppression, cystitis, and myocarditis.
  • $33
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Cinobufotalin
T4A23991108-68-5
Cinobufotalin is a main cardiac toxin in toad, it is a novel anti-HCC agent, it induces growth inhibition and apoptosis in cultured HCC cells through ceramide production. Cinobufotalin is also an effective reversal agent for the multidrug resistance of tu
  • $44
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Licoisoflavone A
TN186366056-19-7
Licoisoflavone A (Phaseoluteone) is an MRP inhibitor and inhibits lipid peroxidation with an IC50 of 7.2 μM.
  • $98
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Reserpine
T079150-55-5
Reserpine (Serpalan) is an alkaloid isolated from the root of Rauwolfia serpentina. As an inhibitor of vesicular monoamine transporter 2 (VMAT2), it suppresses the uptake of norepinephrine into storage vesicles, leading to depletion of catecholamines and serotonin in central and peripheral nerve terminals. It has antihypertensive and antipsychotic effects and can be used to induce gastric ulcer and depression models.
  • $34
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Clarithromycin
T143481103-11-9
Clarithromycin (A-56268) is a Macrolide Antimicrobial. The mechanism of action of clarithromycin is as a Cytochrome P450 3A4 Inhibitor, and Cytochrome P450 3A Inhibitor, and P-Glycoprotein Inhibitor. The chemical classification of clarithromycin is Macrolides.
  • $50
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LY-402913
T27954334970-65-9In house
LY-402913 is a selective inhibitor of the multidrug resistance protein (MRP1).
  • $117
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Estriol
T157150-27-1
Estriol (Oestriol) is a hydroxylated metabolite of ESTRADIOL or ESTRONE that has a hydroxyl group at C3, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During PREGNANCY, a large amount of estriol is produced by the PLACENTA.
  • $33
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Gramicidin
T11301405-97-6
Gramicidin (Gramicidine) is an antimicrobial peptide. Gramicidin dimers form ion channel-like pores in the cell membranes and organelles of bacterial and animal cells, allowing inorganic monovalent ions, such as potassium and sodium ions, to pass freely through the pores by diffusion, disrupting the important ionic gradient between membranes and thus killing the cells by various actions. Gramicidin is effective against Gram-positive bacteria such as Bacillus subtilis and Staphylococcus aureus, but is not as effective against Gram-negative bacteria such as Escherichia coli.
  • $42
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Perindoprilat
T148495153-31-4
Perindoprilat (Perindoprilate) is an angiotensin-converting enzyme inhibitor.
  • $37
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3-(9-Chloro-3-methyl-4-oxoisoxazolo[4,3-c]quinolin-5(4H)-yl)-N-(3,4,5-trimethoxyphenyl)benzeneacetamide
T9944246238-55-1In house
3-(9-Chloro-3-methyl-4-oxoisoxazolo[4,3-c]quinolin-5(4H)-yl)-N-(3,4,5-trimethoxyphenyl)benzeneacetamide inhibits multidrug resistance protein (MRP1).
  • $70
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Enalapril
T160575847-73-3
Enalapril is a dicarbocyl-containing peptide and angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity.
  • $30
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Lisinopril dihydrate
T070683915-83-7
Lisinopril dihydrate (MK-521) is an orally bioavailable, long-acting angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity.
  • $30
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Ketoprofen
T083922071-15-4
Ketoprofen (RP-19583) is a propionic acid derivative and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic effects. It inhibits cyclo-oxygenase I and II, decreasing the formation of prostaglandin and thromboxane precursors. This reduction in prostaglandin synthesis, mediated by prostaglandin synthase, is responsible for its therapeutic effects. Additionally, Ketoprofen decreases thromboxane A2 formation via thromboxane synthase, inhibiting platelet aggregation.
  • $45
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Propafenone
T086654063-53-5
Propafenone (Propafenonum) is only found in individuals that have used or taken this drug. It is an antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated. The electrophysiological effect of propafenone manifests itself in a reduction of upstroke velocity (Phase 0) of the monophasic action potential. In Purkinje fibers, and to a lesser extent myocardial fibers, propafenone reduces the fast inward current carried by sodium ions, which is responsible for the drugs antiarrhythmic actions. Diastolic excitability threshold is increased and effective refractory period prolonged. Propafenone reduces spontaneous automaticity and depresses triggered activity. At very high concentrations in vitro, propafenone can inhibit the slow inward current carried by calcium but this calcium antagonist effect probably does not contribute to antiarrhythmic efficacy.
  • $39
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Indican
T19866487-60-5
Indican (Indoxyl-β-D-glucoside) is a natural protective compound that is used to protect the liver.
  • $31
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Reserpine hydrochloride
T2177216994-56-2
Reserpine hydrochloride is the salt form of Reserpine and acts as an inhibitor of vesicular monoamine transporter 2 (VMAT2). It blocks the uptake of norepinephrine into storage vesicles, leading to the depletion of catecholamines and serotonin at central and peripheral nerve terminals. It has antihypertensive and antipsychotic properties and is commonly used to induce models of gastric ulcer and depression.
  • $35
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Ceefourin 1
T8596315702-40-0
Ceefourin 1 is a highly selective multidrug resistance protein 4 (MRP4) inhibitor.
  • $36
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Prednisone
T101853-03-2
Prednisone (Dehydrocortisone) is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.
  • $33
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Benzocaine
T092494-09-7
Benzocaine is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.
  • $35
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Perindopril erbumine
T1484L107133-36-8
Perindopril erbumine (S9490-3) is the tert-butylamine salt of perindopril, the ethyl ester of a non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. Upon hydrolysis, Perindopril erbumine (S9490-3) is converted to its active form perindoprilat, inhibiting ACE and the conversion of angiotensin I to angiotensin II; consequently, angiotensin II-mediated vasoconstriction and angiotensin II-stimulated aldosterone secretion from the adrenal cortex are inhibited and diuresis and natriuresis ensue.
  • $30
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Flurbiprofen
T02915104-49-4
Flurbiprofen (dl-Flurbiprofen) is an anti-inflammatory analgesic and antipyretic of the phenylalkynoic acid series. It has been shown to reduce bone resorption in periodontal disease by inhibiting CARBONIC ANHYDRASE.
  • $30
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