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5,15-Diacetyl-3-benzoyllathyrol

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🥰Excellent
Catalog No. T4S2014Cas No. 218916-52-0
Alias Euphorbia factor L3

1. 5,15-Diacetyl-3-benzoyllathyrol (Euphorbia factor L3) is a melanine production inhibitor, excellent in inhibiting pigment stagnation and improving the discoloration of the skin or freckles, has excellent stability.

5,15-Diacetyl-3-benzoyllathyrol

5,15-Diacetyl-3-benzoyllathyrol

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🥰Excellent
Purity: 99.98%
Catalog No. T4S2014Alias Euphorbia factor L3Cas No. 218916-52-0
1. 5,15-Diacetyl-3-benzoyllathyrol (Euphorbia factor L3) is a melanine production inhibitor, excellent in inhibiting pigment stagnation and improving the discoloration of the skin or freckles, has excellent stability.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
2 mg$33In StockIn Stock
5 mg$56In StockIn Stock
10 mg$89In StockIn Stock
25 mg$148In StockIn Stock
1 mL x 10 mM (in DMSO)$79In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.98%
Appearance:Solid
Color:White
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Product Introduction

5,15-Diacetyl-3-benzoyllathyrol AI Summary
5,15-Diacetyl-3-benzoyllathyrol exhibits significant bioactivity related to the reversal of P-gp-mediated multidrug resistance in human MCF7/ADM cells, enhancing intensity by 25.0% at 10 µg/mL after 48 hours based on the SRB assay. It has demonstrated an IC50 value of 164.62 µg/mL and a reversal fold of 6.57 relative to control in these cells. Additionally, its octanol-water partition coefficient (log P) is 6.4. Cytotoxicity studies have shown that 5,15-Diacetyl-3-benzoyllathyrol has an IC50 value greater than 50,000.0 nM against mouse RAW264.7 cells, indicating low toxicity at high concentrations. The compound also displays anti-inflammatory properties by inhibiting LPS-induced nitric oxide production in RAW264.7 cells, with an IC50 value around 8300.0 nM. In mouse 4T1 cells, 5,15-Diacetyl-3-benzoyllathyrol exhibits limited cytotoxicity with an IC50 value greater than 10,000.0 nM based on the MTT assay after a 24-hour incubation period. The repeated demonstration of anti-inflammatory activity in mouse RAW264.7 cells was observed with an IC50 value of approximately 8060.0 nM after 3 hours of pre-incubation and subsequent LPS stimulation, measured using a Griess reagent-based assay..
Note: Summary generated by AI. Data source: ChEMBL
Bioactivity
Description
1. 5,15-Diacetyl-3-benzoyllathyrol (Euphorbia factor L3) is a melanine production inhibitor, excellent in inhibiting pigment stagnation and improving the discoloration of the skin or freckles, has excellent stability.
SynonymsEuphorbia factor L3
Chemical Properties
Molecular Weight522.63
FormulaC31H38O7
Cas No.218916-52-0
Smiles[H][C@]12[C@@H](OC(=O)c3ccccc3)[C@@H](C)C[C@]1(OC(C)=O)C(=O)\C(C)=C/[C@@H]1[C@H](CCC(=C)[C@@H]2OC(C)=O)C1(C)C
Relative Density.1.19
Storage & Solubility Information
Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 45 mg/mL (86.1 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+90% Corn Oil: 2 mg/mL (3.83 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.9134 mL9.5670 mL19.1340 mL95.6700 mL
5 mM0.3827 mL1.9134 mL3.8268 mL19.1340 mL
10 mM0.1913 mL0.9567 mL1.9134 mL9.5670 mL
20 mM0.0957 mL0.4783 mL0.9567 mL4.7835 mL
50 mM0.0383 mL0.1913 mL0.3827 mL1.9134 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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