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HIF-1α-IN-8

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Catalog No. T212496

HIF-1α-IN-8 is an orally active inhibitor of HIF-1α with an IC50 of 2.02 μM. It effectively suppresses the expression of inflammatory factors such as IL-6 and NO, reduces hypoxia-induced ROS production and apoptosis in C8-D1A cells, and inhibits the HIF-1α/IKKα/NF-κB signaling pathway. Additionally, it decreases the expression of proteins related to blood-brain barrier permeability. In a high-altitude cerebral edema (HACE) mouse model, HIF-1α-IN-8 lowers brain water content and oxidative stress levels. This compound is suitable for researching high-altitude cerebral edema (HACE).

HIF-1α-IN-8

HIF-1α-IN-8

😃Good
Catalog No. T212496
HIF-1α-IN-8 is an orally active inhibitor of HIF-1α with an IC50 of 2.02 μM. It effectively suppresses the expression of inflammatory factors such as IL-6 and NO, reduces hypoxia-induced ROS production and apoptosis in C8-D1A cells, and inhibits the HIF-1α/IKKα/NF-κB signaling pathway. Additionally, it decreases the expression of proteins related to blood-brain barrier permeability. In a high-altitude cerebral edema (HACE) mouse model, HIF-1α-IN-8 lowers brain water content and oxidative stress levels. This compound is suitable for researching high-altitude cerebral edema (HACE).
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Product Introduction

Bioactivity
Description
HIF-1α-IN-8 is an orally active inhibitor of HIF-1α with an IC50 of 2.02 μM. It effectively suppresses the expression of inflammatory factors such as IL-6 and NO, reduces hypoxia-induced ROS production and apoptosis in C8-D1A cells, and inhibits the HIF-1α/IKKα/NF-κB signaling pathway. Additionally, it decreases the expression of proteins related to blood-brain barrier permeability. In a high-altitude cerebral edema (HACE) mouse model, HIF-1α-IN-8 lowers brain water content and oxidative stress levels. This compound is suitable for researching high-altitude cerebral edema (HACE).
Targets&IC50
HIF1α:2.02 μM
In vitro
HIF-1α-IN-8 (Compound N41) at a concentration of 20 μM for 48 hours inhibits the secretion of inflammatory factors IL-6 and NO in C8-D1A cells. When used at concentrations ranging from 5-50 μM for 12 hours, it reduces hypoxia-induced ROS production and apoptosis in these cells. Additionally, at 5-20 μM for 24 hours, HIF-1α-IN-8 suppresses the expression of key proteins in the HIF-1α/IKKα/NF-κB signaling pathway (HIF-1α, IKKα, p65, IκBα) and decreases the expression of blood-brain barrier permeability-related proteins MMP-9 and AQP-4 in C8-D1A cells.
In vivo
HIF-1α-IN-8 (Compound N41), administered orally at doses of 25-100 mg/kg once daily for three days, reduces brain water content and oxidative stress levels in mice models of high-altitude cerebral edema (HACE).
Chemical Properties
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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