TMX-4113 has potential to be used in cancer that is a phosphodiesterase 6D(PDE6D) and casein kinase 1α(CK1α) degrader [1].

TMX-4113, also referred to as compound 21, demonstrated a pronounced degradation effect on PDE6D and CK1α in MOLT4 cells at a concentration of 1μM over 4 hours. Additionally, varying concentrations of TMX-4113 (0 nM, 40 nM, 200 nM, 1μM) over the same period led to significant degradation of PDE6D in MOLT4 cells. Notably, a dose of 40 nM effectively degraded over 50% of CK1α in MM.1S cells. Western Blot Analysis corroborated these findings, confirming TMX-4113's high degradation preference for both PDE6D and CK1α at a 1 μM concentration in MOLT4 cells, as well as the induced degradation of PDE6D across the tested concentrations.