Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TMX-4113 has potential to be used in cancer that is a phosphodiesterase 6D(PDE6D) and casein kinase 1α(CK1α) degrader [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 10-14 weeks | $ 1,400.00 | |
50 mg | 10-14 weeks | $ 1,820.00 | |
100 mg | 10-14 weeks | $ 2,820.00 |
Description | TMX-4113 has potential to be used in cancer that is a phosphodiesterase 6D(PDE6D) and casein kinase 1α(CK1α) degrader [1]. |
In vitro | TMX-4113, also referred to as compound 21, demonstrated a pronounced degradation effect on PDE6D and CK1α in MOLT4 cells at a concentration of 1μM over 4 hours. Additionally, varying concentrations of TMX-4113 (0 nM, 40 nM, 200 nM, 1μM) over the same period led to significant degradation of PDE6D in MOLT4 cells. Notably, a dose of 40 nM effectively degraded over 50% of CK1α in MM.1S cells. Western Blot Analysis corroborated these findings, confirming TMX-4113's high degradation preference for both PDE6D and CK1α at a 1 μM concentration in MOLT4 cells, as well as the induced degradation of PDE6D across the tested concentrations. |
Molecular Weight | 308.38 |
Formula | C12H12N4O2S2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.