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I-BET762 carboxylic acid

Name: I-BET762 carboxylic acid
Brand: TargetMol
SKU: T13086
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: PROTAC BRD4-binding moiety 2, Molibresib carboxylic acid, GSK525762A carboxylic acid) Copy Product Info

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Synonyms: PROTAC BRD4-binding moiety 2, Molibresib carboxylic acid, GSK525762A carboxylic acid

Catalog No. T13086 Copy Product Info

Purity: 98.50%

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I-BET762 carboxylic acid is a carboxylic acid derivative of I-BET762, a ligand that specifically targets BET, and is primarily used in the synthesis of PROTAC molecules. I-BET762 carboxylic acid is a BRD4 inhibitor with a pIC50 of 5.1.

Cas No. 1300019-38-8

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Pack Size	Price	USA Stock	Global Stock
1 mg	$30	-	In Stock
5 mg	$64	-	In Stock
10 mg	$106	-	In Stock
25 mg	$177	-	In Stock
50 mg	$258	-	In Stock
1 mL x 10 mM (in DMSO)	$71	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:98.50%

Appearance:Solid

Color:Yellow

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	I-BET762 carboxylic acid is a carboxylic acid derivative of I-BET762, a ligand that specifically targets BET, and is primarily used in the synthesis of PROTAC molecules. I-BET762 carboxylic acid is a BRD4 inhibitor with a pIC50 of 5.1.
Targets & IC50	BRD4:5.1 (pIC50)
In vitro	peripheral blood mononuclear cells (PBMC) inhibited by I-BET762 carboxylic acid(pIC50 of <4).
Synonyms	PROTAC BRD4-binding moiety 2, Molibresib carboxylic acid, GSK525762A carboxylic acid

Chemical Properties

Molecular Weight	396.83
Formula	C₂₀H₁₇ClN₄O₃
Cas No.	1300019-38-8
Smiles	O(C)C=1C=C2C(N3C([C@H](CC(O)=O)N=C2C4=CC=C(Cl)C=C4)=NN=C3C)=CC1
Relative Density.	1.44 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (201.6 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5200 mL	12.5999 mL	25.1997 mL	125.9985 mL
5 mM	0.5040 mL	2.5200 mL	5.0399 mL	25.1997 mL
10 mM	0.2520 mL	1.2600 mL	2.5200 mL	12.5999 mL
20 mM	0.1260 mL	0.6300 mL	1.2600 mL	6.2999 mL
50 mM	0.0504 mL	0.2520 mL	0.5040 mL	2.5200 mL
100 mM	0.0252 mL	0.1260 mL	0.2520 mL	1.2600 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Keywords

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Related Tags: I-BET762 carboxylic acid chemical structure | I-BET762 carboxylic acid in vitro | I-BET762 carboxylic acid formula | I-BET762 carboxylic acid molecular weight