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GSK2643943A

Name: GSK2643943A
Brand: TargetMol
SKU: T11485
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11485Cas No. 2449301-27-1

GSK2643943A is a deubiquitylating enzyme (DUB) inhibitor, with an IC 50 of 160 nM for USP20/Ub-Rho. GSK2643943A has anti-tumor efficacy.

GSK2643943A

🥰Excellent

Purity: 97.09%

Catalog No. T11485Cas No. 2449301-27-1

GSK2643943A is a deubiquitylating enzyme (DUB) inhibitor, with an IC 50 of 160 nM for USP20/Ub-Rho. GSK2643943A has anti-tumor efficacy.

Pack Size	Price	Availability
1 mg	$38	In Stock
5 mg	$89	In Stock
10 mg	$148	In Stock
25 mg	$317	In Stock
50 mg	$490	In Stock
100 mg	$723	In Stock
1 mL x 10 mM (in DMSO)	$98	In Stock

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Batch Information

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Purity:97.09%

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COA HPLC HNMR LCMS

Product Introduction

Bioactivity

Description	GSK2643943A is a deubiquitylating enzyme (DUB) inhibitor, with an IC 50 of 160 nM for USP20/Ub-Rho. GSK2643943A has anti-tumor efficacy.
Targets&IC50	USP20/Ub-Rho:160 nM

Chemical Properties

Molecular Weight	277.3
Formula	C₁₇H₁₂FN₃
Cas No.	2449301-27-1
Smiles	Nc1[nH]c2cc(\C=C\c3cccc(F)c3)ccc2c1C#N
Relative Density.	1.33 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (450.78 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (14.42 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6062 mL	18.0310 mL	36.0620 mL	180.3101 mL
5 mM	0.7212 mL	3.6062 mL	7.2124 mL	36.0620 mL
10 mM	0.3606 mL	1.8031 mL	3.6062 mL	18.0310 mL
20 mM	0.1803 mL	0.9016 mL	1.8031 mL	9.0155 mL
50 mM	0.0721 mL	0.3606 mL	0.7212 mL	3.6062 mL
100 mM	0.0361 mL	0.1803 mL	0.3606 mL	1.8031 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc