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Anti-IGFBP-6 Antibody (1Q821)
🥰Excellent
Catalog No. TMAY-02437
Anti-IGFBP-6 Antibody (1Q821) is a Mouse antibody targeting IGFBP-6. Anti-IGFBP-6 Antibody (1Q821) can be used in ELISA.
Anti-IGFBP-6 Antibody (1Q821)
Anti-IGFBP-6 Antibody (1Q821)
🥰Excellent
Catalog No. TMAY-02437
Anti-IGFBP-6 Antibody (1Q821) is a Mouse antibody targeting IGFBP-6. Anti-IGFBP-6 Antibody (1Q821) can be used in ELISA.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-IGFBP-6 Antibody (1Q821) is a Mouse antibody targeting IGFBP-6. Anti-IGFBP-6 Antibody (1Q821) can be used in ELISA. |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 1Q821 |
| Reactivity | Human |
| Application | ELISA |
| Recommended Dose | ELISA: 1:1000-1:2000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IGFBP6 / IBP6 (rh IGFBP6 / IBP6; TMPY-02119; P24592; Met1-Gly240). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Insulin-like growth factor-binding protein 6 (IGFBP6) is a 24-kDa protein that binds insulin-like growth factor 1 (IGF-1) and IGF-2 with high affinity and inhibits IGF action in vitro. The Insulin-like growth factor-binding protein also known as IGFBP serves as a carrier protein for Insulin-like growth factor 1. IGFBPs are distinct but are sharing regions with strong homology. All members of the IGFBP family bind IGF-I and IGF-II with about equal affinity. Insulin-like growth factor (IGF) binding proteins (IGFBPs) have been shown to either inhibit or enhance the action of IGF or act in an IGF-independent manner in the prostate. IGF-binding protein-4 (IGFBP-4) inhibits IGF-I action in vitro and is the most abundant IGFBP in the rodent arterial wall. IGFBP6 is directly downregulated by the beta-catenin/TCF complex in desmoid tumors, and imply a role for the IGF axis in the proliferation of desmoid tumors. There is mounting evidence that the structure of the IGFBP proteins plays a key role in the regulation of IGF bioavailability, by modulating its molecular size, capillary membrane permeability, target tissue specificity, cell membrane adherence, and IGF affinity. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human IGFBP6 / IBP6 Protein (TMPY-02119) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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