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Berberine hydrogen sulphate

Name: Berberine hydrogen sulphate
Brand: TargetMol
SKU: T5S0814
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5S0814Cas No. 633-66-9

Alias Umbellatine Sulfate, Berberine Bisulfate

Berberine hydrogen sulphate (Umbellatine Sulfate) , an alkaloid extracted from several plants, possesses antimicrobial activity against a wide variety of microorganisms including Gram-positive and Gram-negative bacteria, fungi, and protozoa.

Berberine hydrogen sulphate

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Purity: 99.82%

Catalog No. T5S0814Alias Umbellatine Sulfate, Berberine BisulfateCas No. 633-66-9

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
20 mg	$35	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.82%

Color:White to Yellow

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COA LCMS HNMR

Product Introduction

Berberine hydrogen sulphate AI Summary

Berberine hydrogen sulphate exhibits notable anti-parasitic and anticancer properties. It demonstrates antimalarial activity against Plasmodium falciparum with an IC50 of 800.0 nM, antileishmanial activity against Leishmania amazonensis and Leishmania donovani with an IC50 of 17,000.0 nM, and antitrypanosomal activity against Trypanosoma brucei brucei with an IC50 of 1100.0 nM. Furthermore, Berberine hydrogen sulphate shows significant growth inhibition activity against various human tumor cell lines, as evidenced by GI50 values in the nanomolar range, denoting its potential as an anticancer agent. Additionally, it binds to poly(dA.dT) DNA, resulting in a melting temperature change of 3.5 degrees Celsius, and it exhibits cytotoxicity against African green monkey Vero cells with an IC50 above 200,000.0 nM. It also inhibits the recombinant Staphylococcus aureus SrtA enzyme with an IC50 of 11.5 ug/mL..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Berberine hydrogen sulphate (Umbellatine Sulfate) , an alkaloid extracted from several plants, possesses antimicrobial activity against a wide variety of microorganisms including Gram-positive and Gram-negative bacteria, fungi, and protozoa.
Synonyms	Umbellatine Sulfate, Berberine Bisulfate

Chemical Properties

Molecular Weight	433.43
Formula	C₂₀H₁₉NO₈S
Cas No.	633-66-9
Smiles	COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC5=C(C=C4CC3)OCO5)OC.OS(=O)(=O)[O-]
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 85.83 mg/mL (198.03 mM), Sonication is recommended.

DMSO: 1 mg/mL (2.31 mM), Sonication is recommended.

Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.3072 mL	11.5359 mL	23.0718 mL	115.3589 mL

H2O

	1mg	5mg	10mg	50mg
5 mM	0.4614 mL	2.3072 mL	4.6144 mL	23.0718 mL
10 mM	0.2307 mL	1.1536 mL	2.3072 mL	11.5359 mL
20 mM	0.1154 mL	0.5768 mL	1.1536 mL	5.7679 mL
50 mM	0.0461 mL	0.2307 mL	0.4614 mL	2.3072 mL
100 mM	0.0231 mL	0.1154 mL	0.2307 mL	1.1536 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc