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(E/Z)-GSK5182

🥰Excellent
Catalog No. T7709Cas No. 2699724-40-6
Alias GSK5182(Z/E)

(E/Z)-GSK5182 (GSK5182(Z/E)) is a racemic mixture comprising (E)-GSK5182 and (Z)-GSK5182 isomers. It acts as a highly selective and orally active inverse agonist for the estrogen-related receptor γ (ERRγ), demonstrating potency with an IC50 of 79 nM. Additionally, GSK5182 is known to induce the generation of reactive oxygen species (ROS) in hepatocellular carcinoma.

(E/Z)-GSK5182
Other Forms of (E/Z)-GSK5182:
GSK5182T8370877387-37-6
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(E/Z)-GSK5182

🥰Excellent
Purity: 97.58%
Catalog No. T7709Alias GSK5182(Z/E)Cas No. 2699724-40-6
(E/Z)-GSK5182 (GSK5182(Z/E)) is a racemic mixture comprising (E)-GSK5182 and (Z)-GSK5182 isomers. It acts as a highly selective and orally active inverse agonist for the estrogen-related receptor γ (ERRγ), demonstrating potency with an IC50 of 79 nM. Additionally, GSK5182 is known to induce the generation of reactive oxygen species (ROS) in hepatocellular carcinoma.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$74In StockIn Stock
5 mg$179In StockIn Stock
10 mg$289In StockIn Stock
25 mg$529In StockIn Stock
50 mg$786In StockIn Stock
100 mg$1,180-In Stock
1 mL x 10 mM (in DMSO)$197In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:97.58%
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COA HNMR HPLC LCMS

Product Introduction

Bioactivity
Description
(E/Z)-GSK5182 (GSK5182(Z/E)) is a racemic mixture comprising (E)-GSK5182 and (Z)-GSK5182 isomers. It acts as a highly selective and orally active inverse agonist for the estrogen-related receptor γ (ERRγ), demonstrating potency with an IC50 of 79 nM. Additionally, GSK5182 is known to induce the generation of reactive oxygen species (ROS) in hepatocellular carcinoma.
SynonymsGSK5182(Z/E)
Chemical Properties
Molecular Weight417.54
FormulaC27H31NO3
Cas No.2699724-40-6
SmilesCN(C)CCOC1=CC=C(C=C1)C(=C(CCCO)C1=CC=CC=C1)C1=CC=C(O)C=C1
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 95 mg/mL (227.52 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.9 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3950 mL11.9749 mL23.9498 mL119.7490 mL
5 mM0.4790 mL2.3950 mL4.7900 mL23.9498 mL
10 mM0.2395 mL1.1975 mL2.3950 mL11.9749 mL
20 mM0.1197 mL0.5987 mL1.1975 mL5.9875 mL
50 mM0.0479 mL0.2395 mL0.4790 mL2.3950 mL
100 mM0.0239 mL0.1197 mL0.2395 mL1.1975 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Keywords

ROSprogestogenReceptorprogestogen ReceptorEstrogenReceptorEstrogen ReceptorERRγ(E/Z)-GSK-5182(E/Z)-GSK5182(E/Z)GSK5182(E/Z)-GSK 5182(E/Z) GSK5182
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