This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
DENV-IN-10
Catalog No. T78700
DENV-IN-10 is a potent tetravalent inhibitor of the dengue virus, exhibiting half-maximal effective concentrations (EC50s) of 1.36, 0.87, 0.94, and 0.95 μM against the DENV-1, DENV-2, DENV-3, and DENV-4 serotypes, respectively. Functioning as a post-entry replication inhibitor, DENV-IN-10 demonstrates specificity for primate-origin cells [1].
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DENV-IN-10 is a potent tetravalent inhibitor of the dengue virus, exhibiting half-maximal effective concentrations (EC50s) of 1.36, 0.87, 0.94, and 0.95 μM against the DENV-1, DENV-2, DENV-3, and DENV-4 serotypes, respectively. Functioning as a post-entry replication inhibitor, DENV-IN-10 demonstrates specificity for primate-origin cells [1].
In vitro
DENV-IN-10 (10 µM; administered 2, 6, 12, 24 h before or after DENV infection) exhibited no significant antiviral activity when applied either before or immediately after infection. However, its addition 2 hours post-infection reduced infectious virus particle levels, and it remained effective even when administered 24 hours after infection [1]. DENV-IN-10 (10 µM; 24-60 h) decreased viral RNA copy numbers and the expression of DENV-2 viral proteins NS3 and NS5 in infected Huh-7 cells [1]. DENV-IN-10 in a concentration range of 0.1-20 µM significantly inhibited the replication of DENV-2 in primate cell lines, although it showed higher EC50 values in mosquito cells and young hamster kidney cells [1].
Molecular Weight
475.56
Formula
C26H25N3O4S
Storage
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Dose Conversion
You can also refer to dose conversion for different animals.
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Method for preparing DMSO master liquid: mg
drug pre-dissolved in μL DMSO (Master liquid concentration
mg/mL),
Method for preparing in vivo formulation:Take μL
DMSO master liquid, next add μL PEG300, mix and clarify, next add μL
Tween 80,mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation:Take μL
DMSO master liquid, next add μL Corn oil,mix and clarify.
Note:
Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.