FGFR4-IN-19

Name: FGFR4-IN-19
Brand: TargetMol
SKU: T209757
Rating: 4.5 (1 reviews)

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Catalog No. T209757

FGFR4-IN-19 (compound 8B) is a potent covalent inhibitor of fibroblast growth factor receptor 4 (FGFR4) with an IC50 value of 1.2 nM. It achieves high efficiency and selectivity by covalently targeting the rare cysteine (C552) in the FGFR4 kinase domain. FGFR4-IN-19 is applicable for hepatocellular carcinoma (HCC) research.

FGFR4-IN-19

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Catalog No. T209757

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Product Introduction

Bioactivity

Description	FGFR4-IN-19 (compound 8B) is a potent covalent inhibitor of fibroblast growth factor receptor 4 (FGFR4) with an IC50 value of 1.2 nM. It achieves high efficiency and selectivity by covalently targeting the rare cysteine (C552) in the FGFR4 kinase domain. FGFR4-IN-19 is applicable for hepatocellular carcinoma (HCC) research.
Targets&IC50	FGFR1:4370 nM, FGFR2:490 nM, FGFR3:>5000 nM, FGFR4:1.2 nM
In vitro	FGFR4-IN-19 exhibits weak inhibitory activity against FGFR1 (IC 50 = 4.4 μM) and FGFR2 (IC 50 = 490 nM), with all other IC 50 values exceeding 5 μM. This compound shows high selectivity within the FGFR family. It demonstrates effective cellular FGFR4 binding (EC 50 = 52±7 nM) relative to FGFR1-3 (IC 50 >10 μM). Additionally, FGFR4-IN-19 (0.3 μM, 24 h) shows significant antiproliferative activity, effectively blocking the phosphorylation process of FRS2 in Hep3B cells.

Chemical Properties

Formula

C₂₁H₁₄Cl₃N₅O₄

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

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