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AVE-0118 (Synonyms: AVE0118, AVE 0118)

Name: AVE-0118
Brand: TargetMol
SKU: T26689
Price: 67 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T26689 Copy Product Info

Purity: 98.93%

🥰Excellent

AVE-0118 is a potassium channel blocker and suppresses persistent atrial fibrillation.

AVE-0118

Copy Product Info

🥰Excellent

Catalog No. T26689

Synonyms AVE0118, AVE 0118

AVE-0118 is a potassium channel blocker and suppresses persistent atrial fibrillation.

Cas No. 498577-53-0

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Pack Size	Price	USA Stock	Global Stock
1 mg	$67	In Stock	In Stock
5 mg	$142	In Stock	In Stock
10 mg	$193	In Stock	In Stock
25 mg	$337	In Stock	In Stock
50 mg	$498	In Stock	In Stock
100 mg	$725	-	In Stock
500 mg	$1,520	-	In Stock
1 mL x 10 mM (in DMSO)	$171	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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Custom-made molecule. TargetMol’s expert synthesis team delivers cost-effective solutions. Contact us for inquiries. Committed to serving you.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:98.93%

Color:Yellow to Orange

Resource Download

COA HNMR LCMS

Product Introduction

AVE-0118 AI Summary

AVE-0118 inhibits human ERG with an IC50 value of 10000.0 nM. It also shows high plasma protein binding (PPB) across different species, ranging from 83.04% in guinea pigs to 99.34% in humans, indicating a strong affinity for plasma proteins that may affect its pharmacokinetic profile. Additionally, AVE-0118 inhibits human TASK1 when expressed in Xenopus oocytes, as measured by a whole cell voltage clamp assay, with an IC50 value of 600.0 nM. This inhibition of TASK-1 channel current was observed at a +40mV holding potential using a two-electrode voltage clamp assay..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	AVE-0118 is a potassium channel blocker and suppresses persistent atrial fibrillation.
Synonyms	AVE0118, AVE 0118

Chemical Properties

Molecular Weight	479.57
Formula	C₃₀H₂₉N₃O₃
Cas No.	498577-53-0
Smiles	C(NCCC=1C=CC=NC1)(=O)C2=C(C=CC=C2)C3=C(CNC(CC4=CC=C(OC)C=C4)=O)C=CC=C3
Relative Density.	1.182 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (114.69 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0852 mL	10.4260 mL	20.8520 mL	104.2601 mL
5 mM	0.4170 mL	2.0852 mL	4.1704 mL	20.8520 mL
10 mM	0.2085 mL	1.0426 mL	2.0852 mL	10.4260 mL
20 mM	0.1043 mL	0.5213 mL	1.0426 mL	5.2130 mL
50 mM	0.0417 mL	0.2085 mL	0.4170 mL	2.0852 mL
100 mM	0.0209 mL	0.1043 mL	0.2085 mL	1.0426 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc