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Caracemide

Name: Caracemide
Brand: TargetMol
SKU: T14864
Price: 95 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14864Cas No. 81424-67-1

Alias NSC-253272

Caracemide (NSC-253272) inhibits the enzyme ribonucleotide reductase of Escherichia coli and can be utilized in anticancer studies.

Caracemide

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Purity: 99.8%

Catalog No. T14864Alias NSC-253272Cas No. 81424-67-1

Caracemide (NSC-253272) inhibits the enzyme ribonucleotide reductase of Escherichia coli and can be utilized in anticancer studies.

Pack Size	Price	Availability
5 mg	$38	In Stock
10 mg	$53	In Stock
25 mg	$95	In Stock
50 mg	Preferential	In Stock
1 mL x 10 mM (in DMSO)	$41	In Stock

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Purity:99.8%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Caracemide (NSC-253272) inhibits the enzyme ribonucleotide reductase of Escherichia coli and can be utilized in anticancer studies.
In vitro	Caracemide produces severe central nervous system (CNS) toxicity because of the toxic metabolite, methylisocyanate (MIC). Caracemide inactivates R1 by covalent modification at the substrate-binding site[1].
In vivo	After administration of Caracemide (6.6 mg/kg;i.p.), the mercapturic acid derivative AMCC was identified in rats urine[2].
Synonyms	NSC-253272

Chemical Properties

Molecular Weight	189.17
Formula	C₆H₁₁N₃O₄
Cas No.	81424-67-1
Smiles	CNC(=O)ON(C(C)=O)C(=O)NC
Relative Density.	1.259g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 95 mg/mL (502.19 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (17.44 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.2863 mL	26.4313 mL	52.8625 mL	264.3125 mL
5 mM	1.0573 mL	5.2863 mL	10.5725 mL	52.8625 mL
10 mM	0.5286 mL	2.6431 mL	5.2863 mL	26.4313 mL
20 mM	0.2643 mL	1.3216 mL	2.6431 mL	13.2156 mL
50 mM	0.1057 mL	0.5286 mL	1.0573 mL	5.2863 mL
100 mM	0.0529 mL	0.2643 mL	0.5286 mL	2.6431 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc