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HuR

HuR (human antigen R) or ELAV-like protein 1 is a protein that in humans is encoded by the ELAVL1 gene. The protein encoded by this gene is a member of the ELAVL protein family.

CMLD-2
T36493958843-91-9
CMLD-2 is an inhibitor of HuR-ARE interaction (Ki: 350 nM) that competitively binds HuR protein and disrupts its interaction with adenine element-rich (ARE) mRNA targets.CMLD-2 induces apoptosis and exhibits antitumor effects through MAD2 downregulation. CMLD-2 (1-75 μM ; 24-72 h) had an inhibitory effect on the viability of thyroid cancer cells.CMLD-2 (20-30 μM ; 24-48 h) activated caspases and induced apoptosis in H1299 and A549 cells.CMLD-2 (30 μM ; 24-48 h) induced G1 cell cycle arrest in H1299 and A549 cells and mitochondrial perturbation. CMLD-2 (30 μM ; 24-48 h) reduced the expression of HuR and HuR-regulated mRNAs and proteins in H1299 cells.CMLD-2 (35 μM ; 72 h) decreased the directional migration ability of SW1736, 8505C, BCPAP and K1 cells.CMLD-2 induced the migration of SW1736, 8505C, BCPAP and K1 cells with a strong decrease in MAD2 mRNA levels.
  • $98
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SRI-42127
T732862727872-68-4
SRI-42127 is a novel small molecule inhibitor of the RNA regulatory factor HuR, which inhibits tumor growth, attenuates glial activation in a lipopolysaccharide-induced neuroinflammation model, and reduces neuropathic pain after nerve injury by inhibiting the neuroinflammatory response.
  • $58
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NSC243928 mesylate
T7252859988-01-1
NSC243928 mesylate binds to human lymphocyte antigen 6 (LY6), a cell growth inhibitor with anticancer activity, and induces cell death in triple-negative breast cancer cells in a LY6K-dependent manner.
  • $129
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Azaphilone-9
T729201448460-87-4
Azaphilone-9 (AZA-9) functions as an inhibitor of the HuR-ARE RNA interaction, with an inhibition constant (IC50) of 1.2 μM, by targeting the RNA-binding protein Hu antigen R (HuR). As HuR-RNA interactions play a critical role in stabilizing oncogenic mRNAs within tumors, Azaphilone-9 exhibits potential in inhibiting cancer cell growth and progression.
  • $2,870
10-14 weeks
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KH-3
T623981215115-03-9
KH-3 is a potent inhibitor (IC50: 0.35 μM) of the RNA-binding protein Hu antigen R (HuR) and exhibits anti-proliferative effects. KH-3 interferes with HuR-FOXQ1 Mrna interactions, inhibits breast cancer cell invasion, and delays lung colony formation.
  • $1,270
8-10 weeks
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SRI-43265
T874382727872-88-8
SRI-43265 (compound 40) inhibits the dimerization of human antigen R protein (HuR), which is involved in cancer and inflammation pathogenesis [1].
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10-14 weeks
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ZM-32
T887892667585-44-4
ZM-32, a human antigen R (HuR) inhibitor, effectively downregulates the expression of VEGF-A and MMP9, thereby suppressing angiogenesis in breast cancer tumors. It exhibits broad-spectrum antiproliferative effects across various cancer cell lines and demonstrates antitumor efficacy against MDA-MB-231 in mouse models.
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    TM11
    T201170
    TM11, a tanshinone analog, serves as an effective inhibitor of HuR, preventing the formation of HuR-RNA complexes. It also reduces LPS-induced inflammatory responses in murine macrophages.
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    Okicenone
    T28228137018-54-3
    Okicenone is an antibiotic, interferring with HuR RNA binding, HuR trafficking, T-cell activation and cytokine expression.
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    3-6 months
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