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Icotrokinra acetate (Synonyms: PN-235 acetate, JNJ-77242113 acetate, JNJ-2113 acetate)
Catalog No. TP4234 Copy Product Info
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Icotrokinra (JNJ-77242113) acetate is a potent oral selective antagonist of the IL-23 receptor. It inhibits IL-23-induced STAT3 phosphorylation in peripheral blood mononuclear cells (PBMC) with an IC50 of 5.6 pM and reduces IFN-γ production in natural killer (NK) cells induced by IL-23, with an IC50 of 18.4 pM. Icotrokinra acetate demonstrates anti-inflammatory properties in a TNBS-induced rat colitis model and is applicable to research on psoriasis, psoriatic arthritis, and inflammatory bowel diseases.
Icotrokinra acetate
Copy Product Info🥰Excellent
Catalog No. TP4234
Synonyms PN-235 acetate, JNJ-77242113 acetate, JNJ-2113 acetate
Icotrokinra (JNJ-77242113) acetate is a potent oral selective antagonist of the IL-23 receptor. It inhibits IL-23-induced STAT3 phosphorylation in peripheral blood mononuclear cells (PBMC) with an IC50 of 5.6 pM and reduces IFN-γ production in natural killer (NK) cells induced by IL-23, with an IC50 of 18.4 pM. Icotrokinra acetate demonstrates anti-inflammatory properties in a TNBS-induced rat colitis model and is applicable to research on psoriasis, psoriatic arthritis, and inflammatory bowel diseases.
Icotrokinra acetate
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Icotrokinra (JNJ-77242113) acetate is a potent oral selective antagonist of the IL-23 receptor. It inhibits IL-23-induced STAT3 phosphorylation in peripheral blood mononuclear cells (PBMC) with an IC50 of 5.6 pM and reduces IFN-γ production in natural killer (NK) cells induced by IL-23, with an IC50 of 18.4 pM. Icotrokinra acetate demonstrates anti-inflammatory properties in a TNBS-induced rat colitis model and is applicable to research on psoriasis, psoriatic arthritis, and inflammatory bowel diseases. |
| Targets&IC50 | IL-23:7.1 pM (Kd) |
| In vivo | Icotrokinra acetate, administered orally at doses ranging from 0.03 to 10 mg/kg once daily for 7 days, reduces the colon weight-to-length ratio and alleviates weight loss in rats with TNBS-induced colitis. In a rat skin inflammation model, Icotrokinra acetate at doses greater than 10 mg/kg, given orally twice daily for 3 days, inhibits the upregulation of IL-17A and IL-22 induced by IL-23. |
| Synonyms | PN-235 acetate, JNJ-77242113 acetate, JNJ-2113 acetate |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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