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Doxapram

Name: Doxapram
Brand: TargetMol
SKU: T22315
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22315Cas No. 309-29-5

Alias Dopram

Doxapram (Dopram) is a respiratory stimulant that inhibits TASK-1, TASK-3, and TASK-1/TASK-3 heterodimer channels and is used to study ventilatory failure caused by apnea of prematurity and exacerbation of chronic obstructive pulmonary disease.

Doxapram

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Purity: 99.42%

Catalog No. T22315Alias DopramCas No. 309-29-5

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
10 mg	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.42%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Doxapram (Dopram) is a respiratory stimulant that inhibits TASK-1, TASK-3, and TASK-1/TASK-3 heterodimer channels and is used to study ventilatory failure caused by apnea of prematurity and exacerbation of chronic obstructive pulmonary disease.
Targets&IC50	TASK3:37 μM (EC50), TASK1:410 nM (EC50), K+ currents recorded (type I cells):13 mM, TASK1/TASK3:9 μM (EC50)
In vitro	Doxapram inhibits TASK-1 (EC50=410 nM), TASK-3 (EC50=37 μM), TASK-1/TASK-3 (EC50=9 μM) heterodimeric channel function. Doxapram also evoked 3H overflow in a concentration dependent manner, and Doxapram-evoked release was inhibited by the Ca2+ channel blocker nifedipine (5 mM). [1] Doxapram (1-100 mM) caused rapid, reversible and dose-dependent inhibitions of K+ currents recorded in type I cells (IC50=13 mM). Doxapram was also seen to directly inhibit Ca(2+)-independent K+ currents. Doxapram was a more potent inhibitor of the Ca(2+)-activated K+ currents recorded under control conditions. [2]
Synonyms	Dopram

Chemical Properties

Molecular Weight	378.51
Formula	C₂₄H₃₀N₂O₂
Cas No.	309-29-5
Smiles	O=C1N(CC)CC(CCN2CCOCC2)C1(C=3C=CC=CC3)C=4C=CC=CC4
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 50 mg/mL (132.1 mM), Sonication is recommended.

DMSO: 50 mg/mL (132.1 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.28 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6419 mL	13.2097 mL	26.4194 mL	132.0969 mL
5 mM	0.5284 mL	2.6419 mL	5.2839 mL	26.4194 mL
10 mM	0.2642 mL	1.3210 mL	2.6419 mL	13.2097 mL
20 mM	0.1321 mL	0.6605 mL	1.3210 mL	6.6048 mL
50 mM	0.0528 mL	0.2642 mL	0.5284 mL	2.6419 mL
100 mM	0.0264 mL	0.1321 mL	0.2642 mL	1.3210 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc