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PY-60

Name: PY-60
Brand: TargetMol
SKU: T9566
Price: 52 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9566Cas No. 2765218-56-0

PY-60 can effectively activate YAP transcriptional activity against annexin A2 (ANXA2) (Kd value of 1.4 µM). PY-60 activates a pro-proliferative, YAP-dependent transcriptional program in adult animals that are able to remodel the epidermis through proliferation.

PY-60

🥰Excellent

Purity: 99.67%

Catalog No. T9566Cas No. 2765218-56-0

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$52	In Stock	In Stock
5 mg	$123	In Stock	In Stock
10 mg	$197	In Stock	In Stock
25 mg	$396	In Stock	In Stock
50 mg	$569	In Stock	In Stock
100 mg	$786	-	In Stock
200 mg	$1,080	-	In Stock
1 mL x 10 mM (in DMSO)	$135	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.67%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	PY-60 can effectively activate YAP transcriptional activity against annexin A2 (ANXA2) (Kd value of 1.4 µM). PY-60 activates a pro-proliferative, YAP-dependent transcriptional program in adult animals that are able to remodel the epidermis through proliferation.
Targets&IC50	ANXA2:1.4 µM
In vitro	METHODS: PY-60 (20µM, 24 hours) treated 293A cells, and immunoblot analysis of PP2CA-V5 was performed on material obtained by anti-FLAG immunoprecipitation from cells overexpressing ANXA2-FLAG. RESULTS In 293A cells treated with PY-60, the association between ANXA2 and PPP2CA increased significantly. [1]
In vivo	METHODS: PY-60 (5 mg/kg, intravenous injection, 24 hours) was administered to mice, and the changes in plasma levels in mice were evaluated and the intrinsic clearance in mice was measured. RESULTS The half-life (T1/2) was 0.46 h, and the AUC0-24 was 623 ng*h/mL. At the same time, PY-60 showed a rapid clearance rate (133 mL/min/kg). [2]

Chemical Properties

Molecular Weight	313.37
Formula	C₁₆H₁₅N₃O₂S
Cas No.	2765218-56-0
Smiles	C(NCCCC1=NC=CS1)(=O)C=2C=C(ON2)C3=CC=CC=C3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (319.11 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (12.76 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1911 mL	15.9556 mL	31.9112 mL	159.5558 mL
5 mM	0.6382 mL	3.1911 mL	6.3822 mL	31.9112 mL
10 mM	0.3191 mL	1.5956 mL	3.1911 mL	15.9556 mL
20 mM	0.1596 mL	0.7978 mL	1.5956 mL	7.9778 mL
50 mM	0.0638 mL	0.3191 mL	0.6382 mL	3.1911 mL
100 mM	0.0319 mL	0.1596 mL	0.3191 mL	1.5956 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc