Shopping Cart

Your shopping cart is currently empty

PY-60

Name: PY-60
Brand: TargetMol
SKU: T9566
Price: 52 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Hot

Catalog No. T9566Cas No. 2765218-56-0

PY-60 can effectively activate YAP transcriptional activity against annexin A2 (ANXA2) (Kd value of 1.4 µM). PY-60 activates a pro-proliferative, YAP-dependent transcriptional program in adult animals that are able to remodel the epidermis through proliferation.

PY-60

Copy Product Info

😃Good

Hot

Purity: 99.67%

Catalog No. T9566Cas No. 2765218-56-0

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$52	In Stock	In Stock
5 mg	$123	In Stock	In Stock
10 mg	$197	In Stock	In Stock
25 mg	$396	In Stock	In Stock
50 mg	$569	In Stock	In Stock
100 mg	$786	-	In Stock
200 mg	$1,080	-	In Stock
1 mL x 10 mM (in DMSO)	$135	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.67%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	PY-60 can effectively activate YAP transcriptional activity against annexin A2 (ANXA2) (Kd value of 1.4 µM). PY-60 activates a pro-proliferative, YAP-dependent transcriptional program in adult animals that are able to remodel the epidermis through proliferation.
Targets&IC50	ANXA2:1.4 µM
In vitro	METHODS: PY-60 (20µM, 24 hours) treated 293A cells, and immunoblot analysis of PP2CA-V5 was performed on material obtained by anti-FLAG immunoprecipitation from cells overexpressing ANXA2-FLAG. RESULTS In 293A cells treated with PY-60, the association between ANXA2 and PPP2CA increased significantly. [1]
In vivo	METHODS: PY-60 (5 mg/kg, intravenous injection, 24 hours) was administered to mice, and the changes in plasma levels in mice were evaluated and the intrinsic clearance in mice was measured. RESULTS The half-life (T1/2) was 0.46 h, and the AUC0-24 was 623 ng*h/mL. At the same time, PY-60 showed a rapid clearance rate (133 mL/min/kg). [2]

Chemical Properties

Molecular Weight	313.37
Formula	C₁₆H₁₅N₃O₂S
Cas No.	2765218-56-0
Smiles	C(NCCCC1=NC=CS1)(=O)C=2C=C(ON2)C3=CC=CC=C3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (319.11 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (12.76 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1911 mL	15.9556 mL	31.9112 mL	159.5558 mL
5 mM	0.6382 mL	3.1911 mL	6.3822 mL	31.9112 mL
10 mM	0.3191 mL	1.5956 mL	3.1911 mL	15.9556 mL
20 mM	0.1596 mL	0.7978 mL	1.5956 mL	7.9778 mL
50 mM	0.0638 mL	0.3191 mL	0.6382 mL	3.1911 mL
100 mM	0.0319 mL	0.1596 mL	0.3191 mL	1.5956 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc