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Avibactam sodium hydrate

Name: Avibactam sodium hydrate
Brand: TargetMol
SKU: T60711
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T60711Cas No. 2938989-90-1

Alias NXL-104 hydrate

Avibactam sodium hydrate (NXL-104 hydrate) is a highly effective β-lactamase inhibitor that inhibits β-lactamases TEM-1 and CTX-M-15, as well as the carbapenemase produced by Klebsiella pneumoniae and carbapenem-resistant Enterobacteriaceae.

Avibactam sodium hydrate

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Purity: 99.95%

Catalog No. T60711Alias NXL-104 hydrateCas No. 2938989-90-1

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$30	-	In Stock
5 mg	$61	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.95%

Appearance:Solid

Color:Yellow

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Product Introduction

Bioactivity

Description	Avibactam sodium hydrate (NXL-104 hydrate) is a highly effective β-lactamase inhibitor that inhibits β-lactamases TEM-1 and CTX-M-15, as well as the carbapenemase produced by Klebsiella pneumoniae and carbapenem-resistant Enterobacteriaceae.
Targets&IC50	TEM1:8 nM, CTX-M-15:5 nM
In vitro	Avibactam sodium hydrate is a covalent and reversible non-β-lactam β-lactamase inhibitor with IC50 values of 8 nM and 5 nM for the β-lactamases TEM-1 and CTX-M-15, respectively.[1] Although Avibactam sodium hydrate has little or no antimicrobial activity, it effectively inhibits class A and C β-lactamases, and has no significant effect on the activities of metallo-β-lactamases and Fusobacterium oxysporum OXA carbapenemase. [2] When Avibactam sodium hydrate was used in combination with ceftazidime (concentration range 0-256 mg/L), it inhibited the growth of 16 blaKPC-2-positive and 1 blaOXA-232-positive strains of K. pneumoniae with MIC50 and MIC90 of 8 mg/L.[4]
In vivo	In a mouse model infected with K. pneumoniae Y8 strain, Avibactam sodium hydrate in combination with ceftazidime (0.375 mg/g; subcutaneous injection; every 8 hours for 10 days) significantly inhibited bacterial growth and demonstrated some therapeutic effect. [3] After a single subcutaneous injection of Avibactam sodium hydrate (64 mg/kg), its estimated mean terminal half-life against Pseudomonas aeruginosa infection in a neutropenic mouse lung infection model was 0.24 hours. [3]
Synonyms	NXL-104 hydrate

Chemical Properties

Molecular Weight	305.24
Formula	C₇H₁₂N₃NaO₇S
Cas No.	2938989-90-1
Smiles	NC([C@H]1[N@@]2C(N([C@@](CC1)([H])C2)OS(=O)([O-])=O)=O)=O.[Na+].O

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 150 mg/mL (491.42 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	3.2761 mL	16.3806 mL	32.7611 mL	163.8055 mL
5 mM	0.6552 mL	3.2761 mL	6.5522 mL	32.7611 mL
10 mM	0.3276 mL	1.6381 mL	3.2761 mL	16.3806 mL
20 mM	0.1638 mL	0.8190 mL	1.6381 mL	8.1903 mL
50 mM	0.0655 mL	0.3276 mL	0.6552 mL	3.2761 mL
100 mM	0.0328 mL	0.1638 mL	0.3276 mL	1.6381 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc