Ruboxistaurin mesylate

Name: Ruboxistaurin mesylate
Brand: TargetMol
SKU: T3689L
Rating: 4.5 (1 reviews)

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Catalog No. T3689LCas No. 192050-59-2

Alias LY-333531 Mesylate, LY-333531, LY333531, LY 333531

Ruboxistaurin is a PKC beta inhibitor. Ruboxistaurin reduces oxidative stress and attenuates left ventricular hypertrophy and dysfunction in rats with streptozotocin-induced diabetes. Ruboxistaurin attenuates diabetic nephropathy via modulation of TGF-β1/Smad and GRAP pathways. Ruboxistaurin inhibits retinal neovascularization via suppression of phosphorylation of ERK1/2 and Akt.

Ruboxistaurin mesylate

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Catalog No. T3689LAlias LY-333531 Mesylate, LY-333531, LY333531, LY 333531Cas No. 192050-59-2

Pack Size	Price	Availability
25 mg	$668	1-2 weeks
50 mg	$868	1-2 weeks
100 mg	$1,310	1-2 weeks

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Product Introduction

Bioactivity

Description	Ruboxistaurin is a PKC beta inhibitor. Ruboxistaurin reduces oxidative stress and attenuates left ventricular hypertrophy and dysfunction in rats with streptozotocin-induced diabetes. Ruboxistaurin attenuates diabetic nephropathy via modulation of TGF-β1/Smad and GRAP pathways. Ruboxistaurin inhibits retinal neovascularization via suppression of phosphorylation of ERK1/2 and Akt.
Targets&IC50	PKCε:600 nM, PKCδ:250 nM, PKCβII:5.9 nM, PKCη:52 nM, PKCα:360 nM, PKCγ:300 nM, PKCβI:4.7 nM
Synonyms	LY-333531 Mesylate, LY-333531, LY333531, LY 333531

Chemical Properties

Molecular Weight	564.65
Formula	C₂₉H₃₂N₄O₆S
Cas No.	192050-59-2
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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