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Claudin-18.2 Protein-VLP, Mouse, Recombinant (His & Strep)
(Synonyms: Cldn18) Copy Product InfoSynonyms: Cldn18
Catalog No. TMPY-07232 Copy Product Info
Claudin-18.2 Protein-VLP, Mouse, Recombinant (His & Strep) is expressed in HEK293 Cells. The accession number is P56857-3.
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 µg | $460 | 7-10 days | 7-10 days | |
| 20 µg | $773 | 7-10 days | 7-10 days | |
| 50 µg | $1,180 | 7-10 days | 7-10 days | |
| 100 µg | $1,870 | 7-10 days | 7-10 days | |
| 200 µg | $2,800 | 7-10 days | 7-10 days | |
| 500 µg | $6,630 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Immobilized Recombinant Mouse Claudin-18.2 Protein (VLP, Full-Length, His & Strep Tag) at 5 μg/mL (100 μL/well) can bind Osemitamab, the EC50 is 3-15 ng/mL. |
| Description | Claudin-18.2 Protein-VLP, Mouse, Recombinant (His & Strep) is expressed in HEK293 Cells. The accession number is P56857-3. |
| Species | Mouse |
| Expression System | HEK293 Cells |
| Tag | N-His, C-Strep |
| Accession Number | P56857-3 |
| Construction | A DNA sequence encoding the Mouse CLDN18 (Full Length) (P56857-3) (Ser2-Val264) was expressed, with a polyhistidine tag at the N-terminus and a Strep tag at the C-terminus. |
| Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Formulation | Supplied as sterile 50 mM Hepes, 150 mM NaCl, 10% Trehalose, pH 7.2. Please contact us for any concerns or special requirements. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| Synonyms | Cldn18 |
| Research Background | Claudins family member Claudin18 (CLDN18) is a four-pass transmembrane protein with two extracellular loops and cytoplasmic N- and C-tails found in tight junctions. CLDN18 modulates paracellular permeability, polarity, and signaling. CLDN18 deficiency has been associated with atrophic gastritis, spasmolytic polypeptide-expressing metaplasia (SPEM), and asthma. Lung-specific CLDN18.1 modulates alveolar epithelial type II (AT2) cell proliferation and organ size. Restoration of CLDN18.1 expression in human lung cancer cells has been shown to suppress proliferation, inhibiting the IGF-1R/AKT axes. Not expressed in other healthy tissues, gastric mucosa-specific isoform CLDN18.2 expression manifests in primary gastric cancers. CLDN18.2 at the surface of epithelial tumor cells is a target in antibody and CAR-therapies currently in development. |
| Molecular Weight | 30.56 kDa (predicted) |
| Shipping | Proteins are shipped with blue ice. |
| Storage | Samples are stable for up to twelve months from date of receipt at -70℃. Store it under sterile conditions at -70℃ or lower. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
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Related Tags: Claudin-18.2 Protein-VLP, Mouse, Recombinant (His & Strep) chemical structure | Claudin-18.2 Protein-VLP, Mouse, Recombinant (His & Strep) molecular weight
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