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D-NMAPPD

Name: D-NMAPPD
Brand: TargetMol
SKU: T22069
Rating: 4.5 (1 reviews)

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Catalog No. T22069Cas No. 35922-06-6

Alias (1R,2R)-B13

D-NMAPPD ((1R,2R)-B13) is an acid ceramidase inhibitor and ceramide analog with potential antiproliferative activity that modulates ceramide signaling in human melanoma cells. D-NMAPPD is used in the study of colon cancer.

D-NMAPPD

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Catalog No. T22069Alias (1R,2R)-B13Cas No. 35922-06-6

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$105	35 days	35 days
5 mg	$388	35 days	35 days
10 mg	$713	35 days	35 days
50 mg	$2,790	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	D-NMAPPD ((1R,2R)-B13) is an acid ceramidase inhibitor and ceramide analog with potential antiproliferative activity that modulates ceramide signaling in human melanoma cells. D-NMAPPD is used in the study of colon cancer.
In vitro	In rat hippocampal slices, NMDA receptor-mediated field excitatory postsynaptic potentials (fEPSPs) at synapses in the CA1 region were significantly enhanced by pretreatment with the acidic ceramidase inhibitor D-NMAPPD. [1]
Synonyms	(1R,2R)-B13

Chemical Properties

Molecular Weight	422.56
Formula	C₂₃H₃₈N₂O₅
Cas No.	35922-06-6
Smiles	[C@@H]([C@H](NC(CCCCCCCCCCCCC)=O)CO)(O)C1=CC=C(N(=O)=O)C=C1
Relative Density.	1.101 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc