Shopping Cart

Remove All

Your shopping cart is currently empty

Proceed to checkout Continue shopping

Cyclic ADP-ribose (Synonyms: cADPR)

Name: Cyclic ADP-ribose
Brand: TargetMol
SKU: T19253
Rating: 4.5 (1 reviews)

Catalog No. T19253 Copy Product Info

🥰Excellent

Cyclic ADP-ribose (cADPR) is an effective calcium mobilization second messenger synthesized from NAD+ by ADP-ribosyl cyclase. It mainly increases cytosolic calcium through Ryanodine receptor-mediated endoplasmic reticulum release and extracellular influx via the opening of TRPM2 channels.

Cyclic ADP-ribose

Copy Product Info

🥰Excellent

Catalog No. T19253

Synonyms cADPR

Cas No. 119340-53-3

Pack Size	Price	USA Stock	Global Stock	Quantity
500 μg	$1,083	Inquiry	Inquiry

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

Add to Cart

Add to Quotation

Custom-made molecule. TargetMol’s expert synthesis team delivers cost-effective solutions. Contact us for inquiries. Committed to serving you.However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding.

For research use only—not for human use. No sales to individuals. Use as intended only.

Questions

Resource Download

Product Introduction

Bioactivity

Description	Cyclic ADP-ribose (cADPR) is an effective calcium mobilization second messenger synthesized from NAD+ by ADP-ribosyl cyclase. It mainly increases cytosolic calcium through Ryanodine receptor-mediated endoplasmic reticulum release and extracellular influx via the opening of TRPM2 channels.
In vitro	In cells, cyclic ADP ribose (cADPR) plays an important role in the following processes: cell proliferation and differentiation, regulating for example the expansion of mesenchymal stem cells and hematopoietic progenitor cells, neuronal differentiation of PC12 cells and mouse embryonic stem cells Cardiomyocyte differentiation.
In vivo	In mammals, cyclic ADP-ribose (cADPR) plays an important role in the following processes: inflammation and immune response, including neutrophil chemotaxis and T cell activation; smooth muscle cell contraction in arteries and bronchial tubes, involved Hypoxic pulmonary vasoconstriction and the pathogenesis of inflammation / allergic airway diseases; myometrial contractility, which ultimately helps delivery; myocardial cell contraction in adult heart tissue, involved in angiotensin II and β-adrenaline Myocardial hypertrophy and arrhythmia caused by isoproterenol; endocrine and exocrine pancreatic secretion; social behavior of mice, including memory formation and spatial learning, are related to oxytocin secretion and may be related to niacin deficiency. In addition, cyclic ADP-ribose (cADPR) is involved in the activation and fertilization of eggs in seaweeds and sea urchins, early development of sea urchins, abscisic acid signaling in sponges and plants, cell fission in dinoflagellates, and pathogenicity of Toxoplasma gondii.
Synonyms	cADPR

Chemical Properties

Molecular Weight	541.3
Formula	C₁₅H₂₁N₅O₁₃P₂
Cas No.	119340-53-3
Smiles	O[C@H]1[C@@]2(N3C4=C(N=C3)C(=N)N(C=N4)[C@@]5(O[C@@]([C@@H](O)[C@H]5O)(COP(=O)(O)OP(=O)(O)OC[C@@](O2)([C@H]1O)[H])[H])[H])[H]
Relative Density.	2.57 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc