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CZC-25146

Name: CZC-25146
Brand: TargetMol
SKU: T3053
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3053Cas No. 1191911-26-8

Alias CHEMBL2397014

CZC-25146 (CHEMBL2397014) is an effective, specific and metabolically stable LRRK2 inhibitor with IC50 of 4.76/6.87 nM for wild-type LRRK2(Leucine-rich repeat kinase-2) and G2019S LRRK2, respectively.

CZC-25146

🥰Excellent

Purity: 97.68%

Catalog No. T3053Alias CHEMBL2397014Cas No. 1191911-26-8

Pack Size	Price	Availability
10 mg	$48	In Stock
25 mg	$106	In Stock
50 mg	$193	In Stock
100 mg	$276	In Stock
200 mg	$401	In Stock
1 mL x 10 mM (in DMSO)	$31	In Stock

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Purity:97.68%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	CZC-25146 (CHEMBL2397014) is an effective, specific and metabolically stable LRRK2 inhibitor with IC50 of 4.76/6.87 nM for wild-type LRRK2(Leucine-rich repeat kinase-2) and G2019S LRRK2, respectively.
Targets&IC50	LRRK2:4.76 nM, LRRK2 (G2019S):6.87 nM
Synonyms	CHEMBL2397014

Chemical Properties

Molecular Weight	488.54
Formula	C₂₂H₂₅FN₆O₄S
Cas No.	1191911-26-8
Smiles	COc1cc(ccc1Nc1ncc(F)c(Nc2ccccc2NS(C)(=O)=O)n1)N1CCOCC1
Relative Density.	1.436 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (122.81 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0469 mL	10.2346 mL	20.4692 mL	102.3458 mL
5 mM	0.4094 mL	2.0469 mL	4.0938 mL	20.4692 mL
10 mM	0.2047 mL	1.0235 mL	2.0469 mL	10.2346 mL
20 mM	0.1023 mL	0.5117 mL	1.0235 mL	5.1173 mL
50 mM	0.0409 mL	0.2047 mL	0.4094 mL	2.0469 mL
100 mM	0.0205 mL	0.1023 mL	0.2047 mL	1.0235 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc