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Naxitamab

Catalog No. T77448 CAS 1879925-92-4

Synonyms: Naxitamab-gqgk, Humanized 3F8, Hu3F8

Naxitamab (Hu3F8) is a humanized monoclonal antibody against GD2 (hu3F8). Naxitamab has antitumor activity and can be used to study neuroblastoma, osteosarcoma, and other GD2-positive cancers.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Naxitamab

Naxitamab, CAS 1879925-92-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 189.00
5 mg	In stock	$ 476.00
10 mg	In stock	$ 788.00
25 mg	In stock	$ 1,180.00
50 mg	In stock	$ 1,590.00
100 mg	In stock	$ 2,130.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Naxitamab (Hu3F8) is a humanized monoclonal antibody against GD2 (hu3F8). Naxitamab has antitumor activity and can be used to study neuroblastoma, osteosarcoma, and other GD2-positive cancers.
Targets&IC50	LAN1:5.1 μg/mL
In vitro	Naxitamab (Hu3F8; 72 h) exhibits cytotoxicity against the neuroblastoma cell line LAN-1, with an EC50 value of 5.1 μg/mL[1]. Naxitamab (0.1-1 μg/mL; 4 h; peripheral blood mononuclear cells (PBMC) and polymorphonuclear leukocytes (PMN)) demonstrates antibody-dependent cell-mediated cytotoxic effects (ADCC)[1].
In vivo	In athymic nude mice with LAN-1 xenografts, Naxitamab (Hu3F8; 100 mg/kg; intravenous; twice a week for 4 weeks) inhibits tumor growth in neuroblastoma xenografts[1].

Synonyms	Naxitamab-gqgk, Humanized 3F8, Hu3F8
Molecular Weight	N/A
CAS No.	1879925-92-4

Storage

store at low temperature

store at -80°C

References and Literature

1. Cheung NK, et, al. Humanizing murine IgG3 anti-GD2 antibody m3F8 substantially improves antibody-dependent cell-mediated cytotoxicity while retaining targeting in vivo. Oncoimmunology. 2012 Jul 1;1(4):477-486.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Naxitamab 1879925-92-4 Others Naxitamab-gqgk Humanized 3F8 Hu3F8 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.