Shopping Cart

Your shopping cart is currently empty

Thiamphenicol

Name: Thiamphenicol
Brand: TargetMol
SKU: T1550
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T1550Cas No. 15318-45-3

Alias Thiophenicol, Dextrosulphenidol

Thiamphenicol (Dextrosulphenidol) is a methylsulfonyl analog of chloramphenicol. It is an antibiotic and immunosuppressive agent.

Thiamphenicol

Copy Product Info

😃Good

Purity: 99.8%

Catalog No. T1550Alias Thiophenicol, DextrosulphenidolCas No. 15318-45-3

Thiamphenicol (Dextrosulphenidol) is a methylsulfonyl analog of chloramphenicol. It is an antibiotic and immunosuppressive agent.

Pack Size	Price	USA Warehouse	Global Warehouse
500 mg	$31	In Stock	In Stock
1 g	$44	-	In Stock
5 g	$98	-	In Stock
10 g	$153	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.8%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Thiamphenicol AI Summary

Thiamphenicol exhibits a range of bioactivities and physicochemical properties. It has been tested for inhibition of the puromycin reaction, demonstrating an inhibition constant (Ki) of 400.0 nM. The compound has a moderate hydrophobic profile with a low partition coefficient (logP) and a logD7.4 of -0.27, indicating a preference for the aqueous layer over the organic layer at physiological pH. It shows cytotoxic activity against various strains of Streptococcus and inhibition of Streptokinase Promoter Activity, with EC50 values ranging from 740.0 nM to 4552.0 nM. Additionally, it inhibits the PhoP region in Salmonella Typhimurium with IC50 values between 18030.0 nM and 86160.0 nM. Thiamphenicol demonstrates inhibitory effects on several targets, including human tyrosyl-DNA phosphodiesterase 1, malaria parasite plastid, HP1-beta Chromodomain interactions, and Plasmodium falciparum proliferation, with potency values ranging from 2269.5 nM to 89125.1 nM. It has anti-SARS-CoV-2 activity, inhibiting the SARS-CoV-2 3CL-Pro protease by 16.32% at 20µM and reducing cytotoxicity in Caco-2 and VERO-6 cells at various concentrations. The compound exhibits moderate hepatotoxicity, with evidence of acute liver toxicity, and affects several liver function parameters (ALT, AST, ALP, and bilirubin) as well as kidney function markers and blood chemistry parameters. It shows inhibitory activity towards human HDAC6 enzyme, with an inhibition rate of 10.91% using a commercial peptide substrate. In transporter assays, Thiamphenicol inhibits multiple transport proteins such as BSEP, MRP2, MRP3, and MRP4 with relatively low potency (IC50 values >133000.0 nM). It also affects sodium fluorescein uptake in OATP1B3- and OATP1B1-transfected cells, with inhibitions over 100%. Overall, Thiamphenicol has diverse pharmacological effects on multiple biological pathways and targets, suggesting its potential utility in various therapeutic areas, albeit with a cautionary note regarding its hepatotoxic and nephrotoxic potential..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Thiamphenicol (Dextrosulphenidol) is a methylsulfonyl analog of chloramphenicol. It is an antibiotic and immunosuppressive agent.
Synonyms	Thiophenicol, Dextrosulphenidol

Chemical Properties

Molecular Weight	356.22
Formula	C₁₂H₁₅Cl₂NO₅S
Cas No.	15318-45-3
Smiles	[C@@H]([C@H](NC(C(Cl)Cl)=O)CO)(O)C1=CC=C(S(C)(=O)=O)C=C1
Relative Density.	1.3281 g/cm3 (Estimated)

Storage & Solubility Information

Storage

keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (561.45 mM), Sonication is recommended.

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.61 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8073 mL	14.0363 mL	28.0725 mL	140.3627 mL
5 mM	0.5615 mL	2.8073 mL	5.6145 mL	28.0725 mL
10 mM	0.2807 mL	1.4036 mL	2.8073 mL	14.0363 mL
20 mM	0.1404 mL	0.7018 mL	1.4036 mL	7.0181 mL
50 mM	0.0561 mL	0.2807 mL	0.5615 mL	2.8073 mL
100 mM	0.0281 mL	0.1404 mL	0.2807 mL	1.4036 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc