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AMG9810

Name: AMG9810
Brand: TargetMol
SKU: T7189
Price: 43 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7189Cas No. 545395-94-6

AMG 9810 is a competitive antagonist of capsaicin activation of the vanilloid receptor 1 (TRPV1) (IC50s = 24.5 and 85.6 nM for human and rat TRPV1, respectively).

AMG9810

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Purity: 99.95%

Catalog No. T7189Cas No. 545395-94-6

AMG 9810 is a competitive antagonist of capsaicin activation of the vanilloid receptor 1 (TRPV1) (IC50s = 24.5 and 85.6 nM for human and rat TRPV1, respectively).

Pack Size	Price	Availability
5 mg	$43	In Stock
10 mg	$56	In Stock
25 mg	$118	In Stock
50 mg	$215	In Stock
100 mg	$377	In Stock
500 mg	$883	In Stock
1 mL x 10 mM (in DMSO)	$48	In Stock

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Purity:99.95%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	AMG 9810 is a competitive antagonist of capsaicin activation of the vanilloid receptor 1 (TRPV1) (IC50s = 24.5 and 85.6 nM for human and rat TRPV1, respectively).
Targets&IC50	TRPV1 (rat):85.6 nM, TRPV1 (human):24.5 nM
In vivo	In a rat model of inflammatory pain induced by intraplantar injection of complete Freund's adjuvant, 30-100 mg/kg AMG 9810 reverses thermal and mechanical hyperalgesia[3].

Chemical Properties

Molecular Weight	337.41
Formula	C₂₁H₂₃NO₃
Cas No.	545395-94-6
Smiles	CC(C)(C)C1=CC=C(C=C1)\C=C\C(=O)NC1=CC2=C(OCCO2)C=C1
Relative Density.	1.175 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (118.55 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.93 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9638 mL	14.8188 mL	29.6375 mL	148.1877 mL
5 mM	0.5928 mL	2.9638 mL	5.9275 mL	29.6375 mL
10 mM	0.2964 mL	1.4819 mL	2.9638 mL	14.8188 mL
20 mM	0.1482 mL	0.7409 mL	1.4819 mL	7.4094 mL
50 mM	0.0593 mL	0.2964 mL	0.5928 mL	2.9638 mL
100 mM	0.0296 mL	0.1482 mL	0.2964 mL	1.4819 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc