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Phorbol 12,13-dibutyrate

Name: Phorbol 12,13-dibutyrate
Brand: TargetMol
SKU: T16526
Price: 56 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16526Cas No. 37558-16-0

Alias Phorbol dibutyrate, PDBu

Phorbol 12,13-dibutyrate (Phorbol dibutyrate) is a PKC activator that inhibits α1-adrenoceptor-mediated positive inotropic effects in a concentration-dependent manner, induced by contraction of isolated rabbit vascular smooth muscle.

Phorbol 12,13-dibutyrate

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Purity: 99.37%

Catalog No. T16526Alias Phorbol dibutyrate, PDBuCas No. 37558-16-0

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$56	In Stock	In Stock
5 mg	$172	In Stock	In Stock
10 mg	$297	In Stock	In Stock
25 mg	$589	In Stock	In Stock
50 mg	$919	In Stock	In Stock
100 mg	$1,460	-	In Stock
200 mg	$1,970	-	In Stock
1 mL x 10 mM (in DMSO)	$189	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.37%

ee:98.65%

Appearance:Solid

Color:White

Resource Download

COA CSFC HNMR LCMS

Product Introduction

Bioactivity

Description	Phorbol 12,13-dibutyrate (Phorbol dibutyrate) is a PKC activator that inhibits α1-adrenoceptor-mediated positive inotropic effects in a concentration-dependent manner, induced by contraction of isolated rabbit vascular smooth muscle.
In vitro	Phorbol 12,13-dibutyrate (1 μM) activated PKC and inhibited Na/K-ATPase transporter activity in OK cells but not in LLC-PK1 cells [3].
Synonyms	Phorbol dibutyrate, PDBu

Chemical Properties

Molecular Weight	504.61
Formula	C₂₈H₄₀O₈
Cas No.	37558-16-0
Smiles	[H][C@]12[C@]3([H])C=C(CO)C[C@]4(O)C(=O)C(C)=C[C@@]4([H])[C@@]3(O)[C@H](C)[C@@H](OC(=O)CCC)[C@@]1(OC(=O)CCC)C2(C)C
Relative Density.	1.27g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 242.5 mg/mL (480.57 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (7.93 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9817 mL	9.9086 mL	19.8173 mL	99.0864 mL
5 mM	0.3963 mL	1.9817 mL	3.9635 mL	19.8173 mL
10 mM	0.1982 mL	0.9909 mL	1.9817 mL	9.9086 mL
20 mM	0.0991 mL	0.4954 mL	0.9909 mL	4.9543 mL
50 mM	0.0396 mL	0.1982 mL	0.3963 mL	1.9817 mL
100 mM	0.0198 mL	0.0991 mL	0.1982 mL	0.9909 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc