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CCPA

Name: CCPA
Brand: TargetMol
SKU: T21519
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T21519Cas No. 37739-05-2

Alias 2-CHLORO-N-CYCLOPENTYLADENOSINE, 2-chloro-N(6)cyclopentyladenosine

CCPA (2-chloro-N(6)cyclopentyladenosine) is a potent and selective agonist of adenosine A1 receptor

CCPA

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Purity: 99.1%

Catalog No. T21519Alias 2-CHLORO-N-CYCLOPENTYLADENOSINE, 2-chloro-N(6)cyclopentyladenosineCas No. 37739-05-2

CCPA (2-chloro-N(6)cyclopentyladenosine) is a potent and selective agonist of adenosine A1 receptor

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$48	In Stock	In Stock
5 mg	$98	In Stock	In Stock
10 mg	$156	In Stock	In Stock
25 mg	$313	In Stock	In Stock
50 mg	$496	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$108	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.1%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	CCPA (2-chloro-N(6)cyclopentyladenosine) is a potent and selective agonist of adenosine A1 receptor
Targets&IC50	A1 receptor:40 nM
In vitro	CCPA suppressed the mRNA and protein expressions of CnAβ and exerted antihypertrophic effects to a greater degree than CsA. The inhibition of CCPA on cardiomyocyte hypertrophy was counteracted by the A1 receptor antagonist DPCPX[1].
In vivo	CCPA (CCPA) was synthesized as a potential high affinity ligand for A1 adenosine receptors. Binding of [3H]PIA to A1 receptors of rat brain membranes was inhibited by CCPA with a Ki-value of 0.4 nM, compared to a Ki-value of 0.8 nM for the parent compound N6-cyclopentyladenosine (CPA)[2].
Synonyms	2-CHLORO-N-CYCLOPENTYLADENOSINE, 2-chloro-N(6)cyclopentyladenosine

Chemical Properties

Molecular Weight	369.8
Formula	C₁₅H₂₀ClN₅O₄
Cas No.	37739-05-2
Smiles	N(C1=C2C(N(C=N2)[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)=NC(Cl)=N1)C4CCCC4
Relative Density.	1.87 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (148.73 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.41 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7042 mL	13.5208 mL	27.0416 mL	135.2082 mL
5 mM	0.5408 mL	2.7042 mL	5.4083 mL	27.0416 mL
10 mM	0.2704 mL	1.3521 mL	2.7042 mL	13.5208 mL
20 mM	0.1352 mL	0.6760 mL	1.3521 mL	6.7604 mL
50 mM	0.0541 mL	0.2704 mL	0.5408 mL	2.7042 mL
100 mM	0.0270 mL	0.1352 mL	0.2704 mL	1.3521 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc