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Faldaprevir
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Catalog No. T19685Cas No. 801283-95-4
Alias BI-201335, BI201335
Faldaprevir is an orally effective, selective, non-covalent HCV NS3/4A protease inhibitor with high inhibitory activity against HCV 1a and 1b genotypes (Ki=2.6 nM &2.0 nM).Faldaprevir inhibits viral replication by blocking the breakdown of viral precursor proteins, and is well tolerated with good antiviral activity against hepatitis C virus.
Faldaprevir
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Purity: 99.19%
Catalog No. T19685Alias BI-201335, BI201335Cas No. 801283-95-4
Faldaprevir is an orally effective, selective, non-covalent HCV NS3/4A protease inhibitor with high inhibitory activity against HCV 1a and 1b genotypes (Ki=2.6 nM &2.0 nM).Faldaprevir inhibits viral replication by blocking the breakdown of viral precursor proteins, and is well tolerated with good antiviral activity against hepatitis C virus.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $278 | - | In Stock | |
| 5 mg | $678 | - | In Stock | |
| 10 mg | $948 | - | In Stock | |
| 25 mg | $1,380 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.19%
ee:100%
Appearance:Solid
Color:Yellow
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Faldaprevir is an orally effective, selective, non-covalent HCV NS3/4A protease inhibitor with high inhibitory activity against HCV 1a and 1b genotypes (Ki=2.6 nM &2.0 nM).Faldaprevir inhibits viral replication by blocking the breakdown of viral precursor proteins, and is well tolerated with good antiviral activity against hepatitis C virus. |
| In vivo | Methods: After a single intravenous injection of 2 mg/kg or 10 mg/kg oral administration of [(14)C]-Faldaprevir in rats, the metabolism, pharmacokinetics, excretion, and tissue distribution of the hepatitis C NS3/NS4 protease inhibitor were studied. Results: After intravenous administration, the terminal elimination of plasma radioactivity was 1.75 h (male) and 1.74 h (female) respectively. The corresponding AUC0-∞, CL and Vss were 1920 and 1900 ngEq · h/mL, 18.3 and 17.7 mL/min/kg and 2.32 and 2.12 mL/kg for men and women, respectively. After oral administration, the plasma radioactivity of t1/2 and AUC0-∞ was 1.67 and 1.77 h and 11 300 and 17 900 ngEq · h/mL for men and women, respectively. [5] |
| Synonyms | BI-201335, BI201335 |
| Molecular Weight | 869.82 |
| Formula | C40H49BrN6O9S |
| Cas No. | 801283-95-4 |
| Smiles | N(C(=O)[C@H]1N(C([C@@H](NC(OC2CCCC2)=O)C(C)(C)C)=O)C[C@H](OC=3C4=C(N=C(C3)C=5N=C(NC(C(C)C)=O)SC5)C(Br)=C(OC)C=C4)C1)[C@@]6(C(O)=O)[C@H](C=C)C6 |
| Relative Density. | 1.31g/cm3 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||
| Solubility Information | DMSO: 4 mg/mL (4.6 mM), Sonication is recommended. | ||||||||||
Solution Preparation Table | |||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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