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Apamin acetate
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Catalog No. TP1223L
Alias Apamine acetate, Apamin acetate(24345-16-2 Free base)
Apamin acetate (Apamine acetate) is a selective Ca2+-activated blocker of K+ (SK) channels, an 18-amino acid peptide neurotoxin found in bee toxins.Apamin acetate enhances synapse growth and regeneration following laceration injury to cortical neurons.Apamin acetate has anti-inflammatory and anti-fibrotic effects.
Apamin acetate
😃Good
Purity: 96.97%
Catalog No. TP1223LAlias Apamine acetate, Apamin acetate(24345-16-2 Free base)
Apamin acetate (Apamine acetate) is a selective Ca2+-activated blocker of K+ (SK) channels, an 18-amino acid peptide neurotoxin found in bee toxins.Apamin acetate enhances synapse growth and regeneration following laceration injury to cortical neurons.Apamin acetate has anti-inflammatory and anti-fibrotic effects.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $110 | - | In Stock | |
| 5 mg | $248 | - | In Stock | |
| 10 mg | $358 | - | In Stock | |
| 25 mg | $572 | - | In Stock | |
| 50 mg | $773 | - | In Stock | |
| 100 mg | $1,030 | - | In Stock | |
| 200 mg | $1,390 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:96.97%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Apamin acetate (Apamine acetate) is a selective Ca2+-activated blocker of K+ (SK) channels, an 18-amino acid peptide neurotoxin found in bee toxins.Apamin acetate enhances synapse growth and regeneration following laceration injury to cortical neurons.Apamin acetate has anti-inflammatory and anti-fibrotic effects. |
| In vitro | Apamin acetate (0.5-2 µg/mL; 24 h; HSC-T6 cells) treatment effectively diminishes α-SMA expression in TGF-β1-induced HSC-T6 cells. Furthermore, Apamin acetate treatment prevents the activation of p-Smad2/3 and Smad4 induced by TGF-β1.[1] |
| In vivo | Apamin acetate (0.1 mg/kg; i.p.; twice a week; for 4 weeks; C57BL/6 male mice) leads to reduced liver injury and lowered proinflammatory cytokine levels. Additionally, it inhibits collagen deposition, bile duct epithelial cell (BEC) proliferation, and the expression of fibrogenic genes in DDC-fed mice.[1] |
| Synonyms | Apamine acetate, Apamin acetate(24345-16-2 Free base) |
| Smiles | O=C1[C@@]2([H])N(C([C@@H](NC([C@@H](NC([C@@]3([H])NC([C@@H](NC([C@H](CSSC[C@](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CSSC3)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(N)=O)C(N[C@H](C(N)=O)CC4=CN=CN4)=O)=O)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)C)=O)([H])NC([C@@H](NC([C@@H](NC([C@](NC([C@@H](N1)CCC(O)=O)=O)([H])[C@H](O)C)=O)C)=O)CC(C)C)=O)N)=O)CC(N)=O)=O)=O)CCCCN)=O)C)=O)CCC2.CC(O)=O |
| Sequence | Cys-Asn-Cys-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys-Ala-Arg-Arg-Cys-Gln-Gln-His-NH2 (Disulfide bridge: Cys1-Cys11;Cys3-Cys15) |
| Sequence Short | CNCKAPETALCARRCQQH (Disulfide bridge: Cys1-Cys11;Cys3-Cys15) |
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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