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CH-223191

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Catalog No. T2448Cas No. 301326-22-7
Alias CH 223191

CH-223191 is a specific and effective aromatic hydrocarbon receptor (AhR) antagonist, and its IC50 value for inhibiting luciferase activity induced by TCDD is 0.03 μM. CH-223191 can be used in tumor immunotherapy, cytotoxicity research, stem cell research, inflammation research and neuroprotection.

CH-223191

CH-223191

🥰Excellent
Purity: 99.71%
Catalog No. T2448Alias CH 223191Cas No. 301326-22-7
CH-223191 is a specific and effective aromatic hydrocarbon receptor (AhR) antagonist, and its IC50 value for inhibiting luciferase activity induced by TCDD is 0.03 μM. CH-223191 can be used in tumor immunotherapy, cytotoxicity research, stem cell research, inflammation research and neuroprotection.
Pack SizePriceAvailabilityQuantity
5 mg$56In Stock
10 mg$98In Stock
25 mg$178In Stock
50 mg$296In Stock
100 mg$515In Stock
200 mg$739In Stock
500 mg$1,150In Stock
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Purity:99.71%
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Product Introduction

Bioactivity
Description
CH-223191 is a specific and effective aromatic hydrocarbon receptor (AhR) antagonist, and its IC50 value for inhibiting luciferase activity induced by TCDD is 0.03 μM. CH-223191 can be used in tumor immunotherapy, cytotoxicity research, stem cell research, inflammation research and neuroprotection.
Targets&IC50
AhR:30 nM
In vitro
METHODS: HepG2 cells were treated with CH-223191 (0.1-10 μM) for 1 hour, and the protein levels were detected by Western Blot method.
RESULTS: C-223191 reduces the expression of cytochrome P450 1A1 protein caused by TCDD. [1]
In vivo
METHODS: To study the preventive toxic effects of CH-223191 on 2,3,7,8-TCDD, CH-223191 (10 mg/kg) was intraperitoneally injected into male ICR mice once a day for 25 consecutive days.
RESULTS: C-223191 inhibited the expression of liver cytochrome P450 1A1 and the intracellular fat content in hepatocytes, and reduced the AST and ALT activities in mice treated with TCDD. [1]
SynonymsCH 223191
Chemical Properties
Molecular Weight333.39
FormulaC19H19N5O
Cas No.301326-22-7
SmilesCc1ccccc1\N=N\c1ccc(NC(=O)c2ccnn2C)c(C)c1
Relative Density.1.20 g/cm3 (Predicted)
ColorOrange
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
Ethanol: 3.3 mg/mL (9.9 mM), Sonication is recommended.
DMSO: 127 mg/mL (380.94 mM), Sonication is recommended.
Solution Preparation Table
Ethanol/DMSO
1mg5mg10mg50mg
1 mM2.9995 mL14.9975 mL29.9949 mL149.9745 mL
5 mM0.5999 mL2.9995 mL5.9990 mL29.9949 mL
DMSO
1mg5mg10mg50mg
10 mM0.2999 mL1.4997 mL2.9995 mL14.9975 mL
20 mM0.1500 mL0.7499 mL1.4997 mL7.4987 mL
50 mM0.0600 mL0.2999 mL0.5999 mL2.9995 mL
100 mM0.0300 mL0.1500 mL0.2999 mL1.4997 mL

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