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CH-223191 is a specific and effective aromatic hydrocarbon receptor (AhR) antagonist, and its IC50 value for inhibiting luciferase activity induced by TCDD is 0.03 μM. CH-223191 can be used in tumor immunotherapy, cytotoxicity research, stem cell research, inflammation research and neuroprotection.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $56 | In Stock | |
10 mg | $98 | In Stock | |
25 mg | $178 | In Stock | |
50 mg | $296 | In Stock | |
100 mg | $515 | In Stock | |
200 mg | $739 | In Stock | |
500 mg | $1,150 | In Stock |
Description | CH-223191 is a specific and effective aromatic hydrocarbon receptor (AhR) antagonist, and its IC50 value for inhibiting luciferase activity induced by TCDD is 0.03 μM. CH-223191 can be used in tumor immunotherapy, cytotoxicity research, stem cell research, inflammation research and neuroprotection. |
Targets&IC50 | AhR:30 nM |
In vitro | METHODS: HepG2 cells were treated with CH-223191 (0.1-10 μM) for 1 hour, and the protein levels were detected by Western Blot method. RESULTS: C-223191 reduces the expression of cytochrome P450 1A1 protein caused by TCDD. [1] |
In vivo | METHODS: To study the preventive toxic effects of CH-223191 on 2,3,7,8-TCDD, CH-223191 (10 mg/kg) was intraperitoneally injected into male ICR mice once a day for 25 consecutive days. RESULTS: C-223191 inhibited the expression of liver cytochrome P450 1A1 and the intracellular fat content in hepatocytes, and reduced the AST and ALT activities in mice treated with TCDD. [1] |
Synonyms | CH 223191 |
Molecular Weight | 333.39 |
Formula | C19H19N5O |
Cas No. | 301326-22-7 |
Smiles | Cc1ccccc1\N=N\c1ccc(NC(=O)c2ccnn2C)c(C)c1 |
Relative Density. | 1.20 g/cm3 (Predicted) |
Color | Orange |
Appearance | Solid |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | Ethanol: 3.3 mg/mL (9.9 mM), Sonication is recommended. DMSO: 127 mg/mL (380.94 mM), Sonication is recommended. ![]() | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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