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Eformoterol Hemifumarate

Name: Eformoterol Hemifumarate
Brand: TargetMol
SKU: T6505
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T6505Cas No. 43229-80-7

Alias NSC 299587, Formoterol Hemifumarate, CGP 25827A

Formoterol fumarate (Eformoterol Hemifumarate), an effective, specific and long-acting β2-adrenoceptor agonist, is utilized in the treatment of chronic obstructive pulmonary disease(COPD) and asthma.

Eformoterol Hemifumarate

🥰Excellent

Purity: 99.92%

Catalog No. T6505Alias NSC 299587, Formoterol Hemifumarate, CGP 25827ACas No. 43229-80-7

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$34	In Stock	In Stock
10 mg	$56	In Stock	In Stock
25 mg	$123	In Stock	In Stock
50 mg	$228	In Stock	In Stock
100 mg	$342	In Stock	In Stock
200 mg	$497	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$37	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.92%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Formoterol fumarate (Eformoterol Hemifumarate), an effective, specific and long-acting β2-adrenoceptor agonist, is utilized in the treatment of chronic obstructive pulmonary disease(COPD) and asthma.
In vitro	In guinea pig lungs, Formoterol at a concentration of 100 mg/mL inhibits Platelet-Activating Factor (PAF)-induced eosinophil aggregation and suppresses Porcine Pancreatic Elastase (PPE) activity for 2-4 hours. In conscious guinea pigs, Formoterol dose-dependently inhibits histamine-induced plasma protein leakage and bronchoconstriction. Significant inhibition of histamine-induced effects was observed at doses of 10 mg/mL and 100 mg/mL. Additionally, a higher concentration of Formoterol is required to inhibit neutrophil aggregation (induced by Lipopolysaccharides) compared to its ability to suppress granulocyte-independent PPE (induced by histamine).
In vivo	Formoterol is a high-affinity, selective β2-adrenergic receptor agonist that effectively relaxes airway smooth muscles. Similar to salbutamol and salmeterol, it relaxes guinea pig trachea and human bronchi in vitro in a concentration-dependent manner and inhibits the release of antigen-induced inflammatory mediators in human lung slices.
Synonyms	NSC 299587, Formoterol Hemifumarate, CGP 25827A

Chemical Properties

Molecular Weight	804.88
Formula	2C₁₉H₂₄N₂O₄·C₄H₄O₄
Cas No.	43229-80-7
Smiles	OC(=O)\C=C\C(O)=O.COc1ccc(C[C@H](C)NC[C@@H](O)c2ccc(O)c(NC=O)c2)cc1.COc1ccc(C[C@H](C)NC[C@@H](O)c2ccc(O)c(NC=O)c2)cc1
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 247.50 mg/mL (307.50 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.00 mg/mL (2.48 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2424 mL	6.2121 mL	12.4242 mL	62.1211 mL
5 mM	0.2485 mL	1.2424 mL	2.4848 mL	12.4242 mL
10 mM	0.1242 mL	0.6212 mL	1.2424 mL	6.2121 mL
20 mM	0.0621 mL	0.3106 mL	0.6212 mL	3.1061 mL
50 mM	0.0248 mL	0.1242 mL	0.2485 mL	1.2424 mL
100 mM	0.0124 mL	0.0621 mL	0.1242 mL	0.6212 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

The above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc