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sCNH240 (2-Fluoro-N-[3-(3-thienyl)-5-isoxazolyl]benzenesulfonamide) is a potential and selective Rv1625c/Cya activator with good cell permeability and oral activity, IC90=1.24 μM in cholesterol-supplemented 7H12 medium against Mycobacterium tuberculosis (Mtb) H37Rv strain, and inhibition of CYP2C19, CYP2C9 and hERG channels.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $940 | In Stock | |
5 mg | $2,070 | In Stock | |
10 mg | $3,110 | In Stock | |
25 mg | $5,280 | In Stock |
Description | sCNH240 (2-Fluoro-N-[3-(3-thienyl)-5-isoxazolyl]benzenesulfonamide) is a potential and selective Rv1625c/Cya activator with good cell permeability and oral activity, IC90=1.24 μM in cholesterol-supplemented 7H12 medium against Mycobacterium tuberculosis (Mtb) H37Rv strain, and inhibition of CYP2C19, CYP2C9 and hERG channels. |
Targets&IC50 | M. tuberculosis H37Rv:1.24 μM (MIC₉₀), M. tuberculosis (Intracellular):2.93 μM (EC₅₀), Cytotoxicity:>40 μM (CC₅₀) |
In vitro | sCNH240 showed potent anti-TB activity against M. tuberculosis H37Rv (MIC₉₀ = 1.24 μM) and intracellular efficacy (EC₅₀ = 2.93 μM) with low cytotoxicity (CC₅₀ > 40 μM). In a dormancy model, sCNH240 reduced CFU by 1 log₁₀ alone and 4 log₁₀ when combined with BPaL, likely via Rv1625c/Cya activation[1]. |
In vivo | After oral dosing (20 mg/kg) in mice, sCNH240 showed 78% bioavailability and maintained plasma levels above EC₅₀ for over 14 hours. IV dosing showed low clearance and no cardiotoxicity (hERG IC₅₀ > 30 μM)[1]. |
Alias | 2-Fluoro-N-[3-(3-thienyl)-5-isoxazolyl]benzenesulfonamide |
Molecular Weight | 324.35 |
Formula | C13H9FN2O3S2 |
Cas No. | 1357746-77-0 |
Smiles | O=S(=O)(NC=1ON=C(C1)C2=CSC=C2)C=3C=CC=CC3F |
Relative Density. | no data available |
Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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