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sCNH240
🥰Excellent
Catalog No. T204076Cas No. 1357746-77-0
Alias 2-Fluoro-N-[3-(3-thienyl)-5-isoxazolyl]benzenesulfonamide
sCNH240 (2-Fluoro-N-[3-(3-thienyl)-5-isoxazolyl]benzenesulfonamide) is a potential and selective Rv1625c/Cya activator with good cell permeability and oral activity, IC90=1.24 μM in cholesterol-supplemented 7H12 medium against Mycobacterium tuberculosis (Mtb) H37Rv strain, and inhibition of CYP2C19, CYP2C9 and hERG channels.
sCNH240
🥰Excellent
Purity: 98.46%
Catalog No. T204076Alias 2-Fluoro-N-[3-(3-thienyl)-5-isoxazolyl]benzenesulfonamideCas No. 1357746-77-0
sCNH240 (2-Fluoro-N-[3-(3-thienyl)-5-isoxazolyl]benzenesulfonamide) is a potential and selective Rv1625c/Cya activator with good cell permeability and oral activity, IC90=1.24 μM in cholesterol-supplemented 7H12 medium against Mycobacterium tuberculosis (Mtb) H37Rv strain, and inhibition of CYP2C19, CYP2C9 and hERG channels.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $940 | In Stock | |
| 5 mg | $2,070 | In Stock | |
| 10 mg | $3,110 | In Stock | |
| 25 mg | $5,280 | In Stock |
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Purity:98.46%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | sCNH240 (2-Fluoro-N-[3-(3-thienyl)-5-isoxazolyl]benzenesulfonamide) is a potential and selective Rv1625c/Cya activator with good cell permeability and oral activity, IC90=1.24 μM in cholesterol-supplemented 7H12 medium against Mycobacterium tuberculosis (Mtb) H37Rv strain, and inhibition of CYP2C19, CYP2C9 and hERG channels. |
| Targets&IC50 | M. tuberculosis H37Rv:1.24 μM (MIC₉₀), M. tuberculosis (Intracellular):2.93 μM (EC₅₀), Cytotoxicity:>40 μM (CC₅₀) |
| In vitro | sCNH240 showed potent anti-TB activity against M. tuberculosis H37Rv (MIC₉₀ = 1.24 μM) and intracellular efficacy (EC₅₀ = 2.93 μM) with low cytotoxicity (CC₅₀ > 40 μM). In a dormancy model, sCNH240 reduced CFU by 1 log₁₀ alone and 4 log₁₀ when combined with BPaL, likely via Rv1625c/Cya activation[1]. |
| In vivo | After oral dosing (20 mg/kg) in mice, sCNH240 showed 78% bioavailability and maintained plasma levels above EC₅₀ for over 14 hours. IV dosing showed low clearance and no cardiotoxicity (hERG IC₅₀ > 30 μM)[1]. |
| Alias | 2-Fluoro-N-[3-(3-thienyl)-5-isoxazolyl]benzenesulfonamide |
| Molecular Weight | 324.35 |
| Formula | C13H9FN2O3S2 |
| Cas No. | 1357746-77-0 |
| Smiles | O=S(=O)(NC=1ON=C(C1)C2=CSC=C2)C=3C=CC=CC3F |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 16.66 mg/mL (51.36 mM), Sonication is recommended.  DMSO: 50 mg/mL (154.15 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
H2O/DMSO
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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