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sCNH240

🥰Excellent
Catalog No. T204076Cas No. 1357746-77-0
Alias 2-Fluoro-N-[3-(3-thienyl)-5-isoxazolyl]benzenesulfonamide

sCNH240 (2-Fluoro-N-[3-(3-thienyl)-5-isoxazolyl]benzenesulfonamide) is a potential and selective Rv1625c/Cya activator with good cell permeability and oral activity, IC90=1.24 μM in cholesterol-supplemented 7H12 medium against Mycobacterium tuberculosis (Mtb) H37Rv strain, and inhibition of CYP2C19, CYP2C9 and hERG channels.

sCNH240

sCNH240

🥰Excellent
Purity: 99.04%
Catalog No. T204076Alias 2-Fluoro-N-[3-(3-thienyl)-5-isoxazolyl]benzenesulfonamideCas No. 1357746-77-0
sCNH240 (2-Fluoro-N-[3-(3-thienyl)-5-isoxazolyl]benzenesulfonamide) is a potential and selective Rv1625c/Cya activator with good cell permeability and oral activity, IC90=1.24 μM in cholesterol-supplemented 7H12 medium against Mycobacterium tuberculosis (Mtb) H37Rv strain, and inhibition of CYP2C19, CYP2C9 and hERG channels.
Pack SizePriceAvailabilityQuantity
1 mg$940 In Stock
5 mg$2,070 In Stock
10 mg$3,110 In Stock
25 mg$5,280 In Stock
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Purity:99.04%
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Product Introduction

Bioactivity
Description
sCNH240 (2-Fluoro-N-[3-(3-thienyl)-5-isoxazolyl]benzenesulfonamide) is a potential and selective Rv1625c/Cya activator with good cell permeability and oral activity, IC90=1.24 μM in cholesterol-supplemented 7H12 medium against Mycobacterium tuberculosis (Mtb) H37Rv strain, and inhibition of CYP2C19, CYP2C9 and hERG channels.
Targets&IC50
M. tuberculosis H37Rv:1.24 μM (MIC₉₀), M. tuberculosis (Intracellular):2.93 μM (EC₅₀), Cytotoxicity:>40 μM (CC₅₀)
In vitro
sCNH240 showed potent anti-TB activity against M. tuberculosis H37Rv (MIC₉₀ = 1.24 μM) and intracellular efficacy (EC₅₀ = 2.93 μM) with low cytotoxicity (CC₅₀ > 40 μM). In a dormancy model, sCNH240 reduced CFU by 1 log₁₀ alone and 4 log₁₀ when combined with BPaL, likely via Rv1625c/Cya activation[1].
In vivo
After oral dosing (20 mg/kg) in mice, sCNH240 showed 78% bioavailability and maintained plasma levels above EC₅₀ for over 14 hours. IV dosing showed low clearance and no cardiotoxicity (hERG IC₅₀ > 30 μM)[1].
Alias2-Fluoro-N-[3-(3-thienyl)-5-isoxazolyl]benzenesulfonamide
Chemical Properties
Molecular Weight324.35
FormulaC13H9FN2O3S2
Cas No.1357746-77-0
SmilesO=S(=O)(NC=1ON=C(C1)C2=CSC=C2)C=3C=CC=CC3F
Relative Density.no data available
Storage & Solubility Information
Storagestore at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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