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Cholesteryl linoleate

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Catalog No. T5214Cas No. 604-33-1
Alias Linoleic Acid cholesteryl ester, Cholesterol Linoleate, CE(18:2(9Z,12Z))

Cholesteryl linoleate is the major cholesteryl ester in LDL and atherosclerotic lesions. It is present in LDL as a cholesteryl ester that is oxidized to form cholesteryl linoleate hydroperoxides using LDL receptor-associated proteins that are transferred to the plasma membranes of macrophages and CHO cells expressing 15-lipoxygenase.

Cholesteryl linoleate

Cholesteryl linoleate

😃Good
Purity: 99.61%
Catalog No. T5214Alias Linoleic Acid cholesteryl ester, Cholesterol Linoleate, CE(18:2(9Z,12Z))Cas No. 604-33-1
Cholesteryl linoleate is the major cholesteryl ester in LDL and atherosclerotic lesions. It is present in LDL as a cholesteryl ester that is oxidized to form cholesteryl linoleate hydroperoxides using LDL receptor-associated proteins that are transferred to the plasma membranes of macrophages and CHO cells expressing 15-lipoxygenase.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
200 mg$34In StockIn Stock
500 mg$53In StockIn Stock
1 g$77In StockIn Stock
5 g$188-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.61%
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COA HPLC HNMR

Product Introduction

Bioactivity
Description
Cholesteryl linoleate is the major cholesteryl ester in LDL and atherosclerotic lesions. It is present in LDL as a cholesteryl ester that is oxidized to form cholesteryl linoleate hydroperoxides using LDL receptor-associated proteins that are transferred to the plasma membranes of macrophages and CHO cells expressing 15-lipoxygenase.
SynonymsLinoleic Acid cholesteryl ester, Cholesterol Linoleate, CE(18:2(9Z,12Z))
Chemical Properties
Molecular Weight649.08
FormulaC45H76O2
Cas No.604-33-1
SmilesCCCCC\C=C/C\C=C/CCCCCCCC(=O)O[C@H]1CC[C@]2(C)[C@H]3CC[C@]4(C)[C@H](CC[C@H]4[C@@H]3CC=C2C1)[C@H](C)CCCC(C)C
Relative Density.0.96 g/cm3 (Predicted)
Storage & Solubility Information
StoragePure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 50 mg/mL (77.03 mM), Sonication is recommended.
Chloroform: 10 mg/mL (15.41 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2.5 mg/mL (3.85 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
Chloroform/DMSO
1mg5mg10mg50mg
1 mM1.5406 mL7.7032 mL15.4064 mL77.0321 mL
5 mM0.3081 mL1.5406 mL3.0813 mL15.4064 mL
10 mM0.1541 mL0.7703 mL1.5406 mL7.7032 mL
DMSO
1mg5mg10mg50mg
20 mM0.0770 mL0.3852 mL0.7703 mL3.8516 mL
50 mM0.0308 mL0.1541 mL0.3081 mL1.5406 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

InhibitorinhibitEndogenousMetaboliteEndogenous MetaboliteCholesteryl linoleateCE(18:2)
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