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Cholesteryl linoleate

Name: Cholesteryl linoleate
Brand: TargetMol
SKU: T5214
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5214Cas No. 604-33-1

Alias Linoleic Acid cholesteryl ester, Cholesterol Linoleate, CE(18:2(9Z,12Z))

Cholesteryl linoleate is the major cholesteryl ester in LDL and atherosclerotic lesions. It is present in LDL as a cholesteryl ester that is oxidized to form cholesteryl linoleate hydroperoxides using LDL receptor-associated proteins that are transferred to the plasma membranes of macrophages and CHO cells expressing 15-lipoxygenase.

Cholesteryl linoleate

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Purity: 99.61%

Catalog No. T5214Alias Linoleic Acid cholesteryl ester, Cholesterol Linoleate, CE(18:2(9Z,12Z))Cas No. 604-33-1

Pack Size	Price	USA Warehouse	Global Warehouse
200 mg	$34	In Stock	In Stock
500 mg	$53	In Stock	In Stock
1 g	$77	In Stock	In Stock
5 g	$188	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.61%

Appearance:Viscous

Color:White

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	Cholesteryl linoleate is the major cholesteryl ester in LDL and atherosclerotic lesions. It is present in LDL as a cholesteryl ester that is oxidized to form cholesteryl linoleate hydroperoxides using LDL receptor-associated proteins that are transferred to the plasma membranes of macrophages and CHO cells expressing 15-lipoxygenase.
Synonyms	Linoleic Acid cholesteryl ester, Cholesterol Linoleate, CE(18:2(9Z,12Z))

Chemical Properties

Molecular Weight	649.08
Formula	C₄₅H₇₆O₂
Cas No.	604-33-1
Smiles	CCCCC\C=C/C\C=C/CCCCCCCC(=O)O[C@H]1CC[C@]2(C)[C@H]3CC[C@]4(C)[C@H](CC[C@H]4[C@@H]3CC=C2C1)[C@H](C)CCCC(C)C
Relative Density.	0.96 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (77.03 mM), Sonication is recommended.

Chloroform: 10 mg/mL (15.41 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2.5 mg/mL (3.85 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Chloroform/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5406 mL	7.7032 mL	15.4064 mL	77.0321 mL
5 mM	0.3081 mL	1.5406 mL	3.0813 mL	15.4064 mL
10 mM	0.1541 mL	0.7703 mL	1.5406 mL	7.7032 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.0770 mL	0.3852 mL	0.7703 mL	3.8516 mL
50 mM	0.0308 mL	0.1541 mL	0.3081 mL	1.5406 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc