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ALT-100 (Human IgG1)
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Catalog No. T9901A-813 Copy Product Info
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ALT-100 (Human IgG1) is a humanized monoclonal neutralizing antibody targeting extracellular nicotinamide phosphoribosyltransferase (eNAMPT). This product binds specifically to eNAMPT, blocking its function as a damage-associated molecular pattern (DAMP) that induces pro-inflammatory and pro-fibrotic signaling. ALT-100 effectively inhibits eNAMPT-mediated TLR4 activation, reduces the release of inflammatory cytokines, and suppresses tissue remodeling. It serves as an important pharmacological tool for researching post-infarct myocardial fibrosis, acute respiratory distress syndrome (ARDS), and systemic inflammatory response syndrome.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | Inquiry | Inquiry | Inquiry | |
| 5 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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| Description | ALT-100 (Human IgG1) is a humanized monoclonal neutralizing antibody targeting extracellular nicotinamide phosphoribosyltransferase (eNAMPT). This product binds specifically to eNAMPT, blocking its function as a damage-associated molecular pattern (DAMP) that induces pro-inflammatory and pro-fibrotic signaling. ALT-100 effectively inhibits eNAMPT-mediated TLR4 activation, reduces the release of inflammatory cytokines, and suppresses tissue remodeling. It serves as an important pharmacological tool for researching post-infarct myocardial fibrosis, acute respiratory distress syndrome (ARDS), and systemic inflammatory response syndrome. |
| In vitro | ALT-100 (Human IgG1) binds human eNAMPT with high affinity, neutralizing its non-enzymatic cytokine activity. It inhibits eNAMPT-induced TLR4/NF-κB activation in macrophages and myofibroblasts, downregulating pro-inflammatory factors (TNF-α, IL-6) and fibrotic markers (α-SMA) [1][2]. |
| In vivo | In pharmacological studies using mouse models of permanent myocardial infarction (MI), systemic administration of ALT-100 (Human IgG1) (at doses such as 5-10 mg/kg) significantly reduces myocardial infarct size and suppresses post-infarct fibrosis; the treatment leads to a measurable improvement in left ventricular (LV) function, as evidenced by increased ejection fraction and reduced ventricular dilation, confirming its efficacy in mitigating pathological cardiac remodeling [1]. |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | |
| Target | NAMPT |
| Isotype | IgG1 |
| Storage | Store at low temperature Store at -20°C Shipping with blue ice/Shipping at ambient temperature. |
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Related Tags: ALT-100 (Human IgG1) chemical structure | ALT-100 (Human IgG1) in vivo | ALT-100 (Human IgG1) in vitro
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