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Acetohydroxamic acid

Name: Acetohydroxamic acid
Brand: TargetMol
SKU: T1592
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1592Cas No. 546-88-3

Alias oxime, N-Hydroxyacetamide, Methylhydroxamic acid, Lithostat, AHA, Acetic acid

Acetohydroxamic acid (N-Hydroxyacetamide) is an antagonist of the bacterial enzyme urease.

Acetohydroxamic acid

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Purity: 99.91%

Catalog No. T1592Alias oxime, N-Hydroxyacetamide, Methylhydroxamic acid, Lithostat, AHA, Acetic acidCas No. 546-88-3

Acetohydroxamic acid (N-Hydroxyacetamide) is an antagonist of the bacterial enzyme urease.

Pack Size	Price	USA Warehouse	Global Warehouse
100 mg	$29	In Stock	In Stock
500 mg	$54	In Stock	In Stock
1 g	$78	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.91%

Appearance:Solid

Color:White

Resource Download

COA HPLC HNMR

Product Introduction

Acetohydroxamic acid AI Summary

Acetohydroxamic acid exhibits a broad spectrum of bioactivities and inhibitory effects across various biochemical targets. Its notable activities include: 1. **Enzyme Inhibition**: - **Carbonic Anhydrase II**: Inhibits human CA2 enzyme with an IC50 of 47,000 nM. - **Helicobacter pylori Urease**: Demonstrates notable inhibition with IC50 values ranging from 17,000 nM to 184,000 nM in various assays. - **Klebsiella aerogenes Urease**: Exhibits a Ki value of 2,600 nM. - **Jack Bean Urease**: Shows an IC50 of 41,500 nM. - **SARS-CoV-2 3CL-Pro Protease**: Inhibits with a 22.1% effect at 20 µM. - **Matrix Metalloprotease-3 (MMP-3)**: Displays a Kd value of 17,000,000 nM. - **HDAC1**: Inhibits with an IC50 of 625,000 nM. - **Polymerase Kappa**: Highly potent with a potency of 56.2 nM. 2. **Antibacterial and Antiviral Activities**: - **Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, and Escherichia coli**: MIC > 128 µg/mL. - **Helicobacter pylori**: Antibacterial effect with a bacterial eradication rate of 44.4% in in vivo studies. - **SARS-CoV-2**: Exhibits activity against virus-induced cytotoxicity in Vero-6 cells at a concentration of 10 µM. 3. **Other Bioactivities**: - **Human HDAC6**: Shows up to 27.12% inhibition in enzymatic assays. - **Matrix Metalloprotease-13 (MMP-13)**: Displays a binding constant (Kb) of 1,200 nM, indicating competitive inhibition. - **Anthrax Lethal Factor, MMP1, MMP2, MMP3, and MMP8**: Shows varied inhibitory activities. Acetohydroxamic acid also presents potential pharmaceutical applications due to its inhibition of liver enzymes, urease, and carbonic anhydrase, making it a candidate for further research in treating urease-related conditions, bacterial infections, and possibly certain viral infections..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Acetohydroxamic acid (N-Hydroxyacetamide) is an antagonist of the bacterial enzyme urease.
Synonyms	oxime, N-Hydroxyacetamide, Methylhydroxamic acid, Lithostat, AHA, Acetic acid

Chemical Properties

Molecular Weight	75.07
Formula	C₂H₅NO₂
Cas No.	546-88-3
Smiles	C(NO)(C)=O
Relative Density.	1.2269 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (799.25 mM), Sonication is recommended.

H2O: 199.8 mM, Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (26.64 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	13.3209 mL	66.6045 mL	133.2090 mL	666.0450 mL
5 mM	2.6642 mL	13.3209 mL	26.6418 mL	133.2090 mL
10 mM	1.3321 mL	6.6605 mL	13.3209 mL	66.6045 mL
20 mM	0.6660 mL	3.3302 mL	6.6605 mL	33.3023 mL
50 mM	0.2664 mL	1.3321 mL	2.6642 mL	13.3209 mL
100 mM	0.1332 mL	0.6660 mL	1.3321 mL	6.6605 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc