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BIRT-377

Name: BIRT-377
Brand: TargetMol
SKU: T23796
Price: 50 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T23796Cas No. 213211-10-0

Alias BIRT377, BIRT 377

BIRT-377 is a negative allosteric and orally bioavailable inhibitor of ICAM-1 and LFA-1(Ki = 25.8 nM). BIRT-377 inhibits the production of IL-2 and can be used in studies about inflammatory and immune disorders.

BIRT-377

😃Good

Purity: 99.93%

Catalog No. T23796Alias BIRT377, BIRT 377Cas No. 213211-10-0

Pack Size	Price	Availability
1 mg	$50	In Stock
5 mg	$122	In Stock
10 mg	$197	In Stock
25 mg	$455	In Stock
50 mg	$672	In Stock
100 mg	$956	In Stock
500 mg	$1,920	6-8 weeks

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Batch Information

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Purity:99.93%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	BIRT-377 is a negative allosteric and orally bioavailable inhibitor of ICAM-1 and LFA-1(Ki = 25.8 nM). BIRT-377 inhibits the production of IL-2 and can be used in studies about inflammatory and immune disorders.
Synonyms	BIRT377, BIRT 377

Chemical Properties

Molecular Weight	442.13
Formula	C₁₈H₁₅BrCl₂N₂O₂
Cas No.	213211-10-0
Smiles	CN1C(=O)N(C(=O)[C@@]1(C)Cc1ccc(Br)cc1)c1cc(Cl)cc(Cl)c1
Relative Density.	1.552 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (203.6 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2618 mL	11.3089 mL	22.6178 mL	113.0889 mL
5 mM	0.4524 mL	2.2618 mL	4.5236 mL	22.6178 mL
10 mM	0.2262 mL	1.1309 mL	2.2618 mL	11.3089 mL
20 mM	0.1131 mL	0.5654 mL	1.1309 mL	5.6544 mL
50 mM	0.0452 mL	0.2262 mL	0.4524 mL	2.2618 mL
100 mM	0.0226 mL	0.1131 mL	0.2262 mL	1.1309 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc