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LolCDE-IN-2

Name: LolCDE-IN-2
Brand: TargetMol
SKU: T11866
Price: 178 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11866 Copy Product Info

Purity: 99.86%

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LolCDE-IN-2 is a potent and selective inhibitor of the Lol protein (LolCDE) with antibacterial activity. LolCDE-IN-2 exerts its antibacterial activity by blocking the lipoprotein transport system in Gram-negative bacteria. LolCDE-IN-2 has an MIC of 2 μg/ml against Escherichia coli MG1655 and also shows inhibitory activity against Pseudomonas aeruginosa.

Cas No. 2748443-01-6

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Pack Size	Price	USA Stock	Global Stock
1 mg	$178	-	In Stock
5 mg	$448	-	In Stock
10 mg	$723	-	In Stock
25 mg	$1,450	-	In Stock
50 mg	$1,950	-	In Stock
100 mg	$2,630	-	In Stock
1 mL x 10 mM (in DMSO)	$496	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.86%

Appearance:Solid

Color:White

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COA HNMR HPLC

Product Introduction

Bioactivity

Description	LolCDE-IN-2 is a potent and selective inhibitor of the Lol protein (LolCDE) with antibacterial activity. LolCDE-IN-2 exerts its antibacterial activity by blocking the lipoprotein transport system in Gram-negative bacteria. LolCDE-IN-2 has an MIC of 2 μg/ml against Escherichia coli MG1655 and also shows inhibitory activity against Pseudomonas aeruginosa.
In vitro	The P. aeruginosa ΔlolCDE::CTX-lolCDE E. coli strain becomes more susceptible to LolCDE-IN-2 (compound 2A) when either the MexAB-OprM efflux pump is lacking or the permeability of its OM is increased by the expression of the FpvA-ΔP protein; in each case, these strains show an MIC of 16 μg/ml [1]. LolCDE-IN-2 likely interacts with residues in the binding regions of E. coli LolCDE.

Chemical Properties

Molecular Weight	367.40
Formula	C₂₂H₁₇N₅O
Cas No.	2748443-01-6
Smiles	N=1C=CC(=CC1)C2=CNN=C2C=3C=CC=C(OCC=4C=CC5=NC=CN5C4)C3
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (217.75 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7218 mL	13.6091 mL	27.2183 mL	136.0915 mL
5 mM	0.5444 mL	2.7218 mL	5.4437 mL	27.2183 mL
10 mM	0.2722 mL	1.3609 mL	2.7218 mL	13.6091 mL
20 mM	0.1361 mL	0.6805 mL	1.3609 mL	6.8046 mL
50 mM	0.0544 mL	0.2722 mL	0.5444 mL	2.7218 mL
100 mM	0.0272 mL	0.1361 mL	0.2722 mL	1.3609 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.