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GN44028

Name: GN44028
Brand: TargetMol
SKU: T15396
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15396Cas No. 1421448-26-1

Alias N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine

GN44028 (N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine) is a hypoxia-inducible factor inhibitor of (HIF)-1 (IC50: 14 nM). GN44028 inhibits hypoxia-induced HIF-1α transcriptional activity. However, It can not be suppressing HIF-1α mRNA expression, HIF-1α protein accumulation, or HIF-1α/HIF-1β heterodimerization.

GN44028

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Purity: 99.52%

Catalog No. T15396Alias N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amineCas No. 1421448-26-1

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$32	In Stock	In Stock
5 mg	$68	In Stock	In Stock
10 mg	$113	In Stock	In Stock
25 mg	$206	In Stock	In Stock
50 mg	$293	In Stock	In Stock
100 mg	$389	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$76	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.52%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

GN44028 AI Summary

GN44028 exhibits cytotoxicity against various human cell lines, including HeLa, PC3, HepG2, and HCT116, with IC50 values ranging from 1800.0 nM to 25400.0 nM after 72 hours as determined by the MTT assay. Additionally, it shows potent inhibition of hypoxia-induced HIF1alpha transcriptional activity in human HeLa cells, achieving an IC50 of 14.0 nM in a luciferase reporter gene assay. Notably, the ratio of YC-1 IC50 to GN44028 IC50 for hypoxia-induced HIF1alpha transcriptional activity in HeLa cells is reported as 100.0..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	GN44028 (N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine) is a hypoxia-inducible factor inhibitor of (HIF)-1 (IC50: 14 nM). GN44028 inhibits hypoxia-induced HIF-1α transcriptional activity. However, It can not be suppressing HIF-1α mRNA expression, HIF-1α protein accumulation, or HIF-1α/HIF-1β heterodimerization.
Targets&IC50	HIF1:14 nM
Synonyms	N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine

Chemical Properties

Molecular Weight	305.33
Formula	C₁₈H₁₅N₃O₂
Cas No.	1421448-26-1
Smiles	C1c2ccccc2-c2[nH]nc(Nc3ccc4OCCOc4c3)c12
Relative Density.	1.421 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 44 mg/mL (144.11 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.55 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2751 mL	16.3757 mL	32.7514 mL	163.7572 mL
5 mM	0.6550 mL	3.2751 mL	6.5503 mL	32.7514 mL
10 mM	0.3275 mL	1.6376 mL	3.2751 mL	16.3757 mL
20 mM	0.1638 mL	0.8188 mL	1.6376 mL	8.1879 mL
50 mM	0.0655 mL	0.3275 mL	0.6550 mL	3.2751 mL
100 mM	0.0328 mL	0.1638 mL	0.3275 mL	1.6376 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc