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CYM50374

Name: CYM50374
Brand: TargetMol
SKU: T27106
Price: 210 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T27106Cas No. 1314212-81-1

CYM50374 inhibits Sphingosine-1-phosphate receptor 4 (S1P4 ) with an IC50 of µM.

CYM50374

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Purity: 98.96%

Catalog No. T27106Cas No. 1314212-81-1

CYM50374 inhibits Sphingosine-1-phosphate receptor 4 (S1P4 ) with an IC50 of µM.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$210	In Stock	In Stock
5 mg	$497	In Stock	In Stock
10 mg	$678	In Stock	In Stock
25 mg	$953	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.96%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

CYM50374 AI Summary

CYM50374 exhibits antagonist activity at the S1P4 receptor in human U2OS cells expressing the EDG6-linked GAL4-VP16 transcription factor via a TEV protease site/beta-arrestin/TEV protease fusion protein and a beta-lactamase reporter gene, with an IC50 value of 34.0 nM. Additionally, the compound shows significant inhibitory effects on the S1P1 and S1P2 receptors at a concentration of 25 µM, with inhibition rates of 80.0% and 90.0%, respectively..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	CYM50374 inhibits Sphingosine-1-phosphate receptor 4 (S1P4 ) with an IC50 of µM.
Targets&IC50	S1P1 receptor:0.034 µM

Chemical Properties

Molecular Weight	341.42
Formula	C₁₉H₁₉NO₃S
Cas No.	1314212-81-1
Smiles	CC1=C(C=2OC(C(NC3=C(C)C=C(CO)C=C3C)=O)=CC2)SC=C1
Relative Density.	1.271 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (161.09 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9289 mL	14.6447 mL	29.2894 mL	146.4472 mL
5 mM	0.5858 mL	2.9289 mL	5.8579 mL	29.2894 mL
10 mM	0.2929 mL	1.4645 mL	2.9289 mL	14.6447 mL
20 mM	0.1464 mL	0.7322 mL	1.4645 mL	7.3224 mL
50 mM	0.0586 mL	0.2929 mL	0.5858 mL	2.9289 mL
100 mM	0.0293 mL	0.1464 mL	0.2929 mL	1.4645 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc