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Anti-HDAC11 Polyclonal Antibody
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Catalog No. TMAB-06927 Copy Product Info
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Anti-HDAC11 Polyclonal Antibody is a Rabbit antibody targeting HDAC11. Anti-HDAC11 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF,FCM.
Anti-HDAC11 Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $220 | 7-10 days | 7-10 days | |
| 100 μL | $373 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
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| Description | Anti-HDAC11 Polyclonal Antibody is a Rabbit antibody targeting HDAC11. Anti-HDAC11 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF,FCM. |
| Ig Type | IgG |
| Reactivity | Human,Mouse (predicted:Rat,Chicken,Pig,Horse) |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500; FCM: 2μg/Test |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus. Note=Predominantly nuclear. |
| Tissue Specificity | Weakly expressed in most tissues. Strongly expressed in brain, heart, skeletal muscle, kidney and testis. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Histone deacetylases (HDAC) are a family of 11 enzymes that are involved in the regulation of gene activation and silencing by regulating chromatin structure. HDAC11 is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Deacetylation of histones is associated with the condensation of chromatin to a compact structure (heterochromatin) in which the genes are silenced. Each member of the HDAC family exhibits a different, individual substrate specificity and function in vivo. HDACs are known to be associated with a number of well characterized cellular oncogenes and tumour- suppressor genes and inhibitors of HDACs induce growth arrest, differentiation or apoptosis of cancer cells in vitro and in vivo. |
| Immunogen | KLH conjugated synthetic peptide: human HDAC11 |
| Antigen Species | Human |
| Gene Name | HDAC11 |
| Gene ID | |
| Protein Name | Histone deacetylase 11 |
| Uniprot ID | |
| Function | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. |
| Molecular Weight | Theoretical: 39 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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