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Anti-FADS2 Polyclonal Antibody
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Catalog No. TMAB-00651
Alias Fatty acid desaturase 2, FADS2, Delta(6) fatty acid desaturase (D6D;Delta(6) desaturase;Delta-6 desaturase), Acyl-CoA 6-desaturase
Anti-FADS2 Polyclonal Antibody is a Rabbit antibody targeting FADS2. Anti-FADS2 Polyclonal Antibody can be used in WB.
Anti-FADS2 Polyclonal Antibody
Anti-FADS2 Polyclonal Antibody
😃Good
Catalog No. TMAB-00651Alias Fatty acid desaturase 2, FADS2, Delta(6) fatty acid desaturase (D6D;Delta(6) desaturase;Delta-6 desaturase), Acyl-CoA 6-desaturase
Anti-FADS2 Polyclonal Antibody is a Rabbit antibody targeting FADS2. Anti-FADS2 Polyclonal Antibody can be used in WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $222 | 7-10 days | |
| 100 μL | $372 | 7-10 days | |
| 200 μL | $528 | 7-10 days |
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-FADS2 Polyclonal Antibody is a Rabbit antibody targeting FADS2. Anti-FADS2 Polyclonal Antibody can be used in WB. |
| Synonyms | Fatty acid desaturase 2, FADS2, Delta(6) fatty acid desaturase (D6D;Delta(6) desaturase;Delta-6 desaturase), Acyl-CoA 6-desaturase |
| Ig Type | IgG |
| Reactivity | Mouse (predicted:Human,Rat,Chicken,Pig,Cow,Horse,Rabbit) |
| Verified Activity | Sample: Lane 1: Mouse Cerebrum tissue lysates Lane 2: Mouse Heart tissue lysates Primary: Anti-FADS2 (TMAB-00651) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 52 kDa Observed band size: 47 kDa |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Endoplasmic reticulum membrane; Multi-pass membrane protein. |
| Tissue Specificity | Expressed in a wide array of tissues, highest expression is found in liver followed by brain, lung, heart, and retina. A lower level is found in breast tumor when compared with normal tissues; lowest levels were found in patients with poor prognostic inde |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | Members of the fatty acid desaturase (FADS) family, including FADS1, FADS2 and FADS3, regulate the desaturation of fatty acids by introducing double bonds between defined carbons of fatty acyl chains, thereby playing an essential role in the lipid metabolic pathway. Members of this family share N-terminal cytochrome b5-like domains, C-terminal multiple membrane-spanning desaturase regions and 3 histidine box motifs. FADS2 (fatty acid desaturase 2), also known as D6D, DES6, LLCDL2 or TU13, is a 444 amino acid multi-pass membrane protein that localizes to the endoplasmic reticulum and contains one cytochrome b5 heme-binding domain. Expressed in adult and fetal heart and in adult liver, brain, lung and retina, FADS2 functions as a component of a lipid metabolic pathway and catalyzes the first step in the pathway, namely the formation of unsaturated fatty acids from polyunsaturated fatty acids. Defects in the gene encoding FADS2 are the cause of cause of fatty acid delta-6-desaturase deficiency, an affliction that is characterized by skin abnormalities, corneal ulceration and growth failure. Multiple isoforms of FADS2 exist due to alternative splicing events. |
| Immunogen | KLH conjugated synthetic peptide: human FADS2 |
| Antigen Species | Human |
| Gene Name | FADS2 |
| Gene ID | |
| Protein Name | Acyl-CoA 6-desaturase |
| Uniprot ID | |
| Biology Area | Metabolism,Fatty acids,Fatty acid oxidation,Metabolism,Lipid metabolism |
| Function | FADS2 (Fatty acid desaturase 2) catalyses the biosynthesis of highly unsaturated fatty acids from precursor essential polyunsaturated fatty acids (linoleic and alpha-linoleic acid). FADS family members comprise an N-terminal cytochrome b5-like domain and a C-terminal membrane-spanning desaturase. FADS2 is repressed by dietary highly unsaturated fatty acids. Altered expression of FADS2 may be associated with obesity-associated insulin resistance. Genetic studies have linked FADS2 to IQ and attention-deficit/hyperactivity disorder (ADHD). |
| Molecular Weight | Theoretical: 52 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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