Shopping Cart

Remove All

Your shopping cart is currently empty

Proceed to checkout Continue shopping

Spiramycin I

Name: Spiramycin I
Brand: TargetMol
SKU: T12986
Rating: 4.5 (1 reviews)

Catalog No. T12986 Copy Product Info

🥰Excellent

Spiramycin I is a macrolide compound that can be used as an antibiotic and an antiparasitic agent.

Spiramycin I

Copy Product Info

🥰Excellent

Catalog No. T12986

Spiramycin I is a macrolide compound that can be used as an antibiotic and an antiparasitic agent.

Cas No. 24916-50-5

Pack Size	Price	USA Stock	Global Stock	Quantity
100 mg	Inquiry	7-10 days	7-10 days
500 mg	Inquiry	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

Add to Quotation

For research use only—not for human use. No sales to individuals. Use as intended only.

Questions

Resource Download

Product Introduction

Bioactivity

Description	Spiramycin I is a macrolide compound that can be used as an antibiotic and an antiparasitic agent.
Targets&IC50	HeLa cells:34.41 μM, KB cells:31.26 μM, MCF-7 cells:33.11 μM, HepG2 cells:30.51 μM, U87 cells:31.10 μM
In vitro	Methods: The antibacterial mechanism and antibacterial spectrum of spiramycin I were investigated, and the minimum inhibitory concentration (MIC) was determined. Results: Spiramycin I binds to the 50S ribosomal subunit and blocks the peptide chain synthesis channel, thereby exerting antibacterial activity against Gram-positive bacteria. It exhibits inhibitory effects on Bacillus subtilis (B. subtilis), Micrococcus luteus (M. luteus), Staphylococcus aureus (S. aureus), Staphylococcus epidermidis (S. epidermidis), and Streptococcus pneumoniae (S. pneumoniae), with MIC values ranging from 0.5 to 8 μg/mL. Methods: HeLa, KB, MCF-7, HepG2, and U87 cancer cells were treated with various concentrations of spiramycin I (0.1–20 μM) and cultured for 72 h. Results: Spiramycin I showed cytotoxicity against all the above cancer cell lines, with corresponding IC₅₀ values of 34.41, 31.26, 33.11, 30.51, and 31.10 μM, respectively [2].

Chemical Properties

Molecular Weight	843.05
Formula	C₄₃H₇₄N₂O₁₄
Cas No.	24916-50-5
Smiles	O([C@H]1[C@@H](CC=O)C[C@@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](N(C)C)CC2)/C=C/C=C/C[C@@H](C)OC(=O)C[C@@H](O)[C@@H]1OC)[C@H]3[C@H](O)[C@@H](N(C)C)[C@H](O[C@H]4C[C@@](C)(O)[C@@H](O)[C@H](C)O4)[C@@H](C)O3
Relative Density.	1.21g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (94.89 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1862 mL	5.9308 mL	11.8617 mL	59.3085 mL
5 mM	0.2372 mL	1.1862 mL	2.3723 mL	11.8617 mL
10 mM	0.1186 mL	0.5931 mL	1.1862 mL	5.9308 mL
20 mM	0.0593 mL	0.2965 mL	0.5931 mL	2.9654 mL
50 mM	0.0237 mL	0.1186 mL	0.2372 mL	1.1862 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Citations

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc