SEMA3A Protein, Human, Recombinant (hFc)

Name: SEMA3A Protein, Human, Recombinant (hFc)
Brand: TargetMol
SKU: TMPY-00124
Price: 52 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: SemD, Semaphorin 3A, SEMAL, SEMAIII, SEMAD, SEMA1, sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A, Hsema-III, Hsema-I, HH16, coll-1, COLL1) Copy Product Info

Synonyms: SemD, Semaphorin 3A, SEMAL, SEMAIII, SEMAD, SEMA1, sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A, Hsema-III, Hsema-I, HH16, coll-1, COLL1

Catalog No. TMPY-00124 Copy Product Info

SEMA3A Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 87.7 kDa and the accession number is Q14563.

Pack Size	Price	USA Stock	Global Stock
5 µg	$52	-	In Stock
10 µg	$81	-	In Stock
20 µg	$129	-	In Stock
50 µg	$255	-	In Stock
100 µg	$436	7-10 days	7-10 days
200 µg	$745	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:91.6%

Appearance:Lyophilized powder

Color:White

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COA User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	SEMA3A Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 87.7 kDa and the accession number is Q14563.
Species	Human
Expression System	HEK293 Cells
Tag	N-hFc
Accession Number	Q14563
Construction	A DNA sequence encoding the human SEMA3A (NP_006071.1) (Lys26-Phe546) was expressed with the Fc region of human IgG1 at the N-terminus. Predicted N terminal: Glu
Protein Purity	> 90 % as determined by SDS-PAGE.
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	Reconstituted with sterile deionized water to 0.25 mg/mL. Reconstitution conditions may vary depending on the lot.
Synonyms	SemD, Semaphorin 3A, SEMAL, SEMAIII, SEMAD, SEMA1, sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A, Hsema-III, Hsema-I, HH16, coll-1, COLL1
Research Background	Semaphorins are a family of secreted and cell-bound signaling molecules defined by the presence of a common 5 aa Sema domain. They are best characterized in relation to axon guidance during development of the nervous system. The functions of Semaphorins 3A (SEMA3A) are mediated primarily through binding to the Neuropilin-1 (Npn-1) and Plexin-A1 coreceptor complex. Neuropilins lack a signaling-competent cytoplasetmic domain and ensure semaphorin binding, whereas the transmembrane receptor plexin mediates the intracellular response. As the first identified vertebrate semaphorin, SEMA3A functions either as a chemorepulsive agent inhibiting axonal outgrowth, or as a chemoattractive agent stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Its overexpression is associated with schizophrenia which is seen in various human tumor cell lines, and aberrant release is associated with the progression of Alzheimer's disease

Chemical Properties

Molecular Weight

87.7 kDa (predicted)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.