N Cadherin Protein, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 29 kDa and the accession number is P15116.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
100 μg | 5 days | $ 600.00 |
Description | N Cadherin Protein, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 29 kDa and the accession number is P15116. |
Species | Mouse |
Expression System | HEK293 |
Tag | Tag Free |
Accession Number | P15116 |
Synonyms | Ncad, N-cadherin, CDHN, cadherin 2, type 1, N-cadherin (neuronal) |
Construction | A DNA sequence encoding the mouse CDH2 (P15116) (Met1-Ala724) was fused with six amino acids (LEVLFQ) at the C-terminus was expressed and purified. |
Protein Purity | > 80 % as determined by SDS-PAGE |
Molecular Weight | 29 kDa (predicted) |
Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method |
Formulation | Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0. 01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA. |
Reconstitution | A hardcopy of datasheet with reconstitution instructions is sent along with the products. Please refer to it for detailed information. |
Stability & Storage |
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Shipping |
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. |
Research Background | Cadherins are calcium-dependent cell adhesion proteins, and they preferentially interact with themselves in a homophilic manner in connecting cells. Cadherin 2 (CDH2), also known as N-Cadherin (neuronal) (NCAD), is a single-pass transmembrane protein and a cadherin containing 5 cadherin domains. N-Cadherin displays a ubiquitous expression pattern but with different expression levels between endocrine cell types. CDH2 (NCAD) has been shown to play an essential role in normal neuronal development, which is implicated in an array of processes including neuronal differentiation and migration, and axon growth and fasciculation. In addition, N-Cadherin expression was upregulated in human HSC during activation in culture, and function or expression blocking of N-Cadherin promoted apoptosis. During apoptosis, N-Cadherin was cleaved into 20-100 kDa fragments. It may provide a novel target for therapies that are directed toward intimal proliferative disorders, including restenosis and vascular bypass graft failure. N-Cadherin is associated with tumor aggressiveness and metastatic potential and may contribute to tumor progression. |
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N Cadherin Protein, Mouse, Recombinant Ncad N-cadherin cadherin 2, type 1, N-cadherin neuronal CDHN cadherin 2, type 1, N-cadherin (neuronal) recombinant recombinant-proteins proteins protein